Publication in the EMBO Journal for the de Bruin Lab

The de Bruin lab show that macrophages are found in both G0‐ and G1‐like phases,
and the latter are permissive to HIV‐1 due to the canonical Raf/MEK/ERK
pathway which deactivates SAMHD1 by CDK1‐mediated phosphorylation at T592.
Therefore, HIV‐1 does not need to encode a SAMHD1 antagonist.

Lab Reference: