Olukunbi Mosaku

The focus of my research
is to gain an understanding of the molecular mechanisms behind familial
Parkinson’s disease (PD). Mutations of the alpha-synuclein protein (encoded by
SNCA) have been shown to cause an autosomal dominant form of PD. We have
generated human induced pluripotent stem cells (hiPSCs) from patients with
familial PD.  Using CRISPR technology we intend
to correct the disease causing mutation in patient hiPSCs.  Furthermore we will introduce this mutation
into control hiPSC lines. This approach allows us to look for disease related
phenotypes in a genetically stable background, after differentiation into
specialised functional cell types.