Journal of Cell Biology for Joe Grove and Mark Marsh

The cell biology of receptor-mediated virus entry

Authors

Joe Grove and Mark Marsh

Abstract

The cell imposes multiple barriers to virus entry. However, viruses
exploit fundamental cellular processes to gain entry to
cells and deliver their genetic cargo. Virus entry
pathways are largely defined by the interactions between virus particles
and their receptors at the cell surface. These
interactions determine the mechanisms of virus attachment, uptake,
intracellular
trafficking, and, ultimately, penetration to the
cytosol. Elucidating the complex interplay between viruses and their
receptors
is necessary for a full understanding of how these
remarkable agents invade their cellular hosts.

Lab Reference: 
Mark Marsh Research Group