Christin is developing technologies that facilitate high-throughput screening projects. This includes the characterization of reporter gene functions in various assays related to cancer signaling and autophagy, and the use of RNAi and CRISPR-mediated gene silencing technologies. Recently, through an award from the Michael J Fox Foundation, Christin started to investigate novel drug targets for Parkin-mediated mitophagy in Parkinsons disease.
Niccolo is working on a project to identify mechanisms of post-translational regulation of the autophagy protease ATG4B. Using siRNA-based high-throughput screening and proteomic technologies, he focusses on the role of kinase signaling in autophagy modulation. This work is sponsored by a project grant from BBSRC.
Jack is a PhD student interested in metabolic signaling. He studies the role of metabolic enzymes in mitogenic signaling and investigates possible links between metabolic enzymes and autophagy.
Krisna studies the role of protein kinase signaling in autophagy. She is an expert in protein purification and crystallization and is developing in vitro assays to study kinase and protease functions by high-throughput screening.