Jamie is working on the regulatory control of autophagy. He is focussing on small molecule compounds that enhance or repress autophagy using cell lines and primary cell cultures. Jamie has recently been awarded an award from Cellular Dynamics to study autophagy in iPS-cell derived neuronal cells.
Janos is manager of the Bioinformatics Image Analysis Core Facility at the LMCB. He is developing image analysis tools for high-content screening of three-dimensional culture systems. He aims to identify small molecule inhibitors of autophagy in 3D model systems.
Niccolo is working on a project to identify mechanisms of post-translational regulation of the autophagy protease ATG4B. Using siRNA-based high-throughput screening and proteomic technologies, he focusses on the role of kinase signaling in autophagy modulation. This work is sponsored by a project grant from BBSRC.
Christin is developing technologies that facilitate high-throughput screening projects. This includes the characterization of reporter gene functions in various assays related to cancer signaling and autophagy, and the use of RNAi and CRISPR-mediated gene silencing technologies.
Krisna studies the role of protein kinase signaling in autophagy. She is an expert in protein purification and crystallization and is developing in vitro assays to study kinase and protease functions by high-throughput screening.
Jack is a PhD student interested in metabolic signaling. He studies the role of metabolic enzymes in mitogenic signaling and investigates possible links between metabolic enzymes and autophagy.