Pelin Candarlioglu (Postdoctoral researcher): I aim to utilize molecular biophysical and cellular biology techniques to investigate how circulating cancer stem cells (CTCs) control their cell cycle and cell fate, in order to further understand how CTCs contribute to metastasis.
HeLa cells stably expressing H2B-mCherry and alpha-tubulin-GFP were filmed at 10x magnification through time lapse microscopy every 30 minutes for 5 days to determine cell cycle in 3 consecutive cell divisions as a model for cancer cell cycle kinetics.
Ginger Hunter (Postdoctoral researcher): I take a genetic, biophysical and cell biological approach to investigate how cytoskeletal mechanics and regulation contribute to the efficiency of Notch-Delta mediated patterning of the Drosophila notum.
Via the process of lateral inhibition, these 3 cells in the Drosophila pupal notum have switched from an epithelial cell fate to a neural cell fate and will eventually contribute to the formation of bristles on the adult fly thorax. F-actin (red), cell membrane (green).
Jigna Patel (Research assistant): In a follow up to a genetic screen performed in the lab, I am studying asymmetry in cell division time and cytokinesis defects.
A typical cytokinesis failure leading to multinucleation in HeLa cells. DNA (blue), tubulin (green), actin (red), cytochrome C (gray).