Cell Biology of Virus Infection
obligate intracellular parasites viruses intimately rely on host cell factors
for all stages of their replication. Our
group is interested in deciphering the complex interactions that occur between poxviruses
and their host cells during all stages of the infection cycle. We investigate how
viruses initiate their internalization by endocytosis, and how they utilize transport
within cellular endocytic systems to their advantage. We are also analyzing how the viral genome and
accessory proteins escape into the cytosol, and how replication proceeds.
these we combine cellular, molecular, and virological techniques with state-of-the-art
technologies such as automated small compound and image-based siRNA screening, advanced
proteomics, live cell microscopy, and electron microscopy. Our particular
interests lie in uncovering novel mechanisms by which viruses subjugate host
cell functions to facilitate their entry, replication, and spread.