Bioinformatics Image Core BIONIC

Manager: Dr. Janos Kriston-Vizi

Janos Kriston-Vizi Marie Curie grant LMCB Bioinformatics Image Core cell biology image processing image analysis bioinformatics MRC UCL high-content analysis high throughput screening high-content screening

The Bioinformatics Image Core provides services for researchers
from various areas in cell biology and
analysis of large data
sets from high-throughput screening experiments.

The Bioinformatics Image Core (BIONIC) facility supports:


  • the high-throughput
    screening activities at the Translational Research
    Resource Centre

  • the image processing and data
    analysis throughout the CBU/LMCB

 

LMCB Bioinformatics Image Core cell biology image processing image analysis bioinformatics MRC UCL high-content analysis high throughput screening high-content screening

 

 Advanced microscopic technology is allowing imaging approaches to detect cellular dynamics with increasing spatial and temporal
resolution. New approaches are required to allow
effective analysis and quantitation of the data,
requiring individuals with advanced skills in image
analysis and computing.

 The core facility has experience in image analysis, statistical methods for analyzing
large data sets and experience in automation processes. as well as a good
understanding of genomic technologies and the drug
discovery process. We have experience
in operation of
PerkinElmer Opera high-content screening microscope. The core's activity is based on image analysis
softwares
ImageJ and Acapella as well as the statistical
program R with Bioconductor packages
such as CellHTS2. Furthermore, we have some experience in tissue culture
and basic laboratory techniques.

Equipment of the Bioinformatics Image Core

 

LMCB Bioinformatics Image Core cell biology image processing image analysis bioinformatics MRC UCL high-content analysis high throughput screening high-content screening
ASUS Server Z8PE-D18
144 GB memory
2x Quad-Core Intel® Xeon® E5520 CPUs (16 cores)

Corsair Hydro H50 High Performance Liquid
 CPU Cooler
NVidia Quadro FX3800
Linux
LMCB Bioinformatics Image Core cell biology image processing image analysis bioinformatics MRC UCL high-content analysis high throughput screening high-content screening

 

 

LMCB Bioinformatics Image Core cell biology image processing image analysis bioinformatics MRC UCL high-content analysis high throughput screening high-content screening
Tyan FT48-B8812 High Performance Barebone System
256 GB memory
4x 12-Core AMD® Opteron® 6174 CPUs (48 cores)
NVidia GeForce GTX 580
Acer GN245HQ 3D monitor with NVidia 3D Vision
Linux

 

LMCB Bioinformatics Image Core cell biology image processing image analysis bioinformatics MRC UCL high-content analysis 

Ultima 9550i Tyrannosaur MKIII
Intel Core i7 3770K 3.50GHz @ 4.60GHz 8-Core
DDR3 32GB Ivybridge
Nvidia GTX 680 
Asus VG278H 3D monitor with NVidia 3D Vision 2

 

UCL Drug Design - Phenotypic Screening course supporting files

ImageJ/Fiji Cell Outliner plugin compiled files.

- Using the link at the bottom of the page download Cell_Outliner.txt and copy into Imagej/Fiji "Plugins" folder.

- Rename the file extension from .txt to .zip

- Uncompress the Cell_Outliner.zip file.

- Start Imagej/Fiji.

 

 

  

 

Publications