Information for module GENEG006
This module is available for: The current academic year
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|Module code:||GENEG006(Add to my personalised list)|
|Title:||Understanding Bioinformatics Resources and Their Application|
|Division:||Division of Biosciences|
|Module organiser:||Dr Ruth Lovering|
|Organiser's location:||Rayne Institute|
|Available for students in Year(s):|
|Module prerequisites:||Available to MSc Genetics of Human Disease Students Only|
|Module outline:||Competency in genomic and proteomic resources is an essential skill for human disease genetic researchers, in this the post-genome era. This module will enable students to experience first-hand how the annotation of the human genome is achieved and understand the uses and limitations of a wide range of freely available online resources. Students will be required to undertake their own literature review of a limited number of genes, or biological field, and to provide accurate gene annotations, using Gene Ontology (GO). Gene Ontology is an established resource for linking the accrued knowledge about individual genes to each gene record in a database. In addition, the GO dataset is invaluable for the analysis of data derived from a wide variety of high-throughput methodologies. The course has four themes: (1) Gene Ontology annotation and application, (2) Online biological databases and their use for gene/SNP mapping, coding region identification, data extraction, including Ensembl, EntrezGene, UniProt, Biomart, OMIM, ChEBI, (3) Analysis of protein sequences and structure, including sequence alignment, structural and/or functional motif recognition, structure prediction, protein evolution, (4) Regulation of gene transcription, providing an introduction to this research area and the methods used to characterise proteins involved in gene regulation.|
|Module aims:||To achieve a comprehensive understanding of GO To gain experience in gene annotation To gain experience in a wide variety of online genomic databases and resources To learn how to review and evaluate the scientific literature describing a gene of interest To gain an insight into the regulation of gene transcription|
|Module objectives:||To understand how the GO database is populated with annotations and how it can be used for the analysis of high-throughput data. To understand how and when to use a variety of online genomic and proteomic databases and resources To understand how to critically evaluate scientific papers To develop independent investigative skills and presentation skills To understand the principles of gene regulation and its relevance to human disease.|
|Key skills provided by module:|
|Module assessment:||Gene summary presentation (10 minutes) 20.00%.|
Seen three-hour multiple choice test 10.00%.
Independent project: SNP report (1,500 words) 70.00%.
|Taking this module as an option?:|
|Link to virtual learning environment(registered students only)||http://moodle.ucl.ac.uk/course/view.php?id=10301|
|Last updated:||2012-07-19 14:09:48 by|