Information for module CELL2008
This module is available for: The current academic year
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|Module code:||CELL2008(Add to my personalised list)|
|Title:||Integrative Cell Biology|
|Division:||Division of Biosciences|
|Module organiser:||Dr. Geraint Thomas|
|Organiser's location:||Cell & Developmental Biology|
|Available for students in Year(s):||2,|
|Module prerequisites:||Open to negotiation but BIOC1001 (or BIOC1001 plus CDEV1001 from 2013 onwards) and either BIOC2001 or BIOL2004 are usual.|
|Module outline:||This new 1-unit course is a combination of two 0.5 unit courses CELL2006 Cell Biology and CELL2007 The Principles of Cellular Control - for information you should also study the database entries describing these two courses. CELL2008 explicitly fuses the contents of CELL2006 and CELL2007 in order to emphasise the importance of integrating the insights obtained in each. Consequently CELL2008 will teach you the major areas of contemporary cell biology including the mechanistics of cell signal transduction at an intermediate level in order to provide a foundation for more specialised third year courses. CELL2008 begins with a new broad-based study of eukaryotic cell biology that introduces how different parts of the cell are formed and function, and how one cell differs from another. In the second half of the course a detailed study of cell signalling mechanisms establishes a fusion between molecular-scale concepts with macroscopic biology. Coursework forms an important part of your study and is designed to illustrate specific cellular processes and techniques in greater detail. As with CELL2007 the course contains a compulsory one-week laboratory component (during the February reading week) that will provide a hands-on introduction to; 1/ Techniques of mammalian cell culture, propagation and transfection with foreign DNA; 2/ Fluorescent and visible light microscopy; 3/ The deduction of the organisation of signaling pathways through epigenetic study of C. elegans with mutations in genes coding signaling proteins; 4/ The application of basic bioinformatics to studies of signalling molecules.|
|Module aims:||CELL2008 will cover the major areas of contemporary eukaryotic cell biology - including the mechanistics of cell signal transduction - at an intermediate level in order to provide a foundation for more specialised third year courses. CELL2008 will introduce the you to much more detailed aspects of eukaryotic cell biology than those covered in the first-year BIOC1001 and CDEV1001 courses. Through the study of examples you will understand how molecular-scale mechanisms orchestrate cellular process and events.|
|Module objectives:||CELL2008 will provide a context in which students will learn how to fuse an understanding of molecular scale concepts and mechanisms with cell biological, metabolic and developmental consequences. In this way, comprehension of both the scope and the limitations of molecular genetic and biochemical interventions in the investigation of the processes of life will be arrived at. We will provide up-to-date coverage of the following:- cell structure and function, function of organelles and intracellular compartmentalisation, organelle biogenesis and protein/membrane trafficking (including the transport of proteins to the nucleus, endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, mitochondria, chloroplast, secretory vesicles, plasma membrane, as well as processes such as endocytosis and exocytosis), structure and function of biological membranes, structure and function of the cytoskeleton (including microtubules, microfilaments etc), cell division and the cell cycle, experimental methods used in cell biology (including tissue culture, microscopy, and protein expression and analysis techniques), cell specialization and differentiation, multicellular life (including stem cells, cell turnover and programmed cell death), the molecular properties of different classes of receptors, the structure-function relationships of kinases, small and heterotrimeric G-proteins, second messenger molecules and the enzymes that generate them, structure-function in the recognition and binding of phosphoproteins and second messengers, signalling through polyphosphoinositides, integration of molecular-scale information into an understanding of major signaling pathways, adrenalin, insulin and EGF and the Wnt/catenin signaling pathways in example processes like energy metabolism, cancer biology, circadian rhythmicity and tissue differentiation|
|Key skills provided by module:||Cell and tissue culture techniques. Data manipulation and presentation. Computer techniques applicable to molecular and cellular biology. Creation of html documents and publication of web pages.|
|Module assessment:||Project report 10.00%.|
Practical report three (30 questions) 5.00%.
Practical report two (30 questions) 5.00%.
Practical report one (30 questions) 5.00%.
In-class test three (12 questions) 5.00%.
In-class test two (12 questions) 5.00%.
In-class test one (40 questions) 5.00%.
Unseen three-hour written examination 60.00%.
|Notes:||The "practical week" component starts on the Monday of the February "reading week" (usually the 6th week of the spring term).|
|Taking this module as an option?:|
|Link to virtual learning environment(registered students only)||https://moodle.ucl.ac.uk/course/view.php?id=18576|
|Last updated:||2012-09-07 15:37:40 by|