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Information for module BIOC3016

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Module code:BIOC3016(Add to my personalised list)
Title:Genes to Disease
Credit value:.5
Division:Division of Biosciences
Module organiser:Professor Kaila Srai
Organiser's location:Room G16 Darwin Building UCL
Organiser's email:k.srai@ucl.ac.uk
Available for students in Year(s):3,
Module prerequisites:Students wishing to take this module are strongly encouraged to have: EITHER (1) a strong biochemistry background/iBSc background OR (2) a 2.1 or higher average in Year 2 AND must have taken and achieved a 2.1 or higher in a cell biology-related course or a course in genetic or physiological systems. This module cannot accommodate more than 60 students. Should the module size exceed 60, the criteria outlined above will become mandatory for confirmation of enrolment on BIOC3016. 
Module outline:This course is suitable for intercalating medical students, third year BSc students including those studying biochemistry, natural sciences, biomedical sciences and neuroscience and MRES students. It is important to have a basic understanding of genetics, biochemistry and cell biology. This half course unit will cover characteristic genetic features of different diseases and will focus on the disease mechanisms and role of genetic abnormalities in a variety of neurodegenerative diseases. Neurodegenerative diseases are a very important cause of morbidity and mortality and with an ageing population they are becoming more prevalent. This course will explore the potential role that genetics play in these diseases and a description of the mutations that have been identified. It will cover our current understanding of the impact of the various disease related mutations at the biochemical, cell and molecular biological levels with an emphasis upon their relationship to the underlying pathology. Subjects covered include: genetics, linkage analysis and genetic heterogeneity, molecular basis of disease, patterns of inheritance and mutation mechanisms. The aetiology and disease mechanisms of Parkinson's, Alzheimer's, Prion, Huntington's, hereditary spastic paraparesis, motor neuron, Friedreich's ataxia, peripheral neuropathy and mitochondrial DNA diseases will be explored. Various general themes will also be developed including: the role of genetic models to study the diseases, the importance of protein aggregation, mitochondrial pathology, free radical damage, metals and the use of stem cells to study and treat the diseases  
Module aims:To introduce students to: advanced aspects of molecular genetics; the relationship between genes and diseases at the molecular level and our current understanding of the disease mechanisms of important human neurodegenerative diseases.  
Module objectives:Students will learn basic and advanced molecular genetics, an understanding of the genetic basis of a variety of neurodegenerative diseases and how this has improved knowledge of pathogenetic mechanisms as well as establishing a broad spectrum of academic and transferable skills.  
Key skills provided by module: 
Module timetable:https://cmis.adcom.ucl.ac.uk:4443/timetabling/moduleTimet.do?firstReq=Y&moduleId=BIOC3016 
Module assessment:Unseen two-hour written examination 70.00%.
Coursework (Paper Analysis) 15.00%.
Summative Test 15.00%. 
Notes: 
Taking this module as an option?: 
Link to virtual learning environment(registered students only) 
Last updated:2014-02-24 18:42:27 by