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Information for module ANAT3028

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Module code:ANAT3028(Add to my personalised list)
Title:The Neurobiology of Neurodegenerative Disease
Credit value:.5
Division:Division of Biosciences
Module organiser:Professor Stephen W Davies
Organiser's location:Anatomy Building
Organiser's email:s.w.davies@ucl.ac.uk
Available for students in Year(s):3,
Module prerequisites:A basic understanding of neuroanatomy and neuroscience. 
Module outline:The last few years have seen a remarkable increase in our understanding of the basic biological mechanisms underlying human neurodegenerative diseases. Identification of mutations in a variety of genes, found to encode proteins present in neuro-pathological inclusions, has suggested that a common feature of all these diseases might be the intracellular accumulation of fibrous protein aggregates within neurons, resulting in neuronal cell death. This course will discuss this novel hypothesis in the light of contemporary research, and provide a foundation for our current understanding of neurodegenerative diseases. The 0.5 CU version of the module (ANAT3028) consists of the lecture series and is examined by one three-hour exam, whereas this 1.0 CU version (ANAT3029) comprises the same lectures and exam, but additionally requires submission of a 6,000 word dissertation together with a short (10 minute) oral presentation. It is recommended that students start thinking about their coursework essay in Term 1, even though the lectures are in Term 2. 
Module aims:I. To provide a detailed description of the clinical symptoms, natural history and pathological basis of several named neurodegenerative diseases. II. To discuss recent advances in our understanding of the novel mechanisms underlying the genetic basis for neurological disease. III. To discuss the mechanisms of protein aggregation within neurons. IV. To discuss the mechanisms of cell death. V. To discuss the processes of prion mediated transmissability and infectivity. V. To actively debate and discuss the relevance of the mechanisms outlined in II-V to the diseases presented in I.  
Module objectives:This course will focus on the genetics, cellular and molecular biology of Alzheimer, Huntington, Parkinson, Motor Neurone and Prion diseases, with the main emphasis on the mechanisms leading to cell death. A combination of lectures and video presentations will cover topics including: * Huntington disease and the polyQ expansion diseases * Parkinson disease and synucleinopathies * Alzheimer Disease, the processing of beta-amyloid and Tau protein * Diseases of Motor Neurons * FrontoTemporal Dementia, progranulin, TDP-43 and FUS/TLS * Prions; Creutzfeld Jacob Disease (CJD) and new variant CJD * The pathways to neuronal cell death; mechanisms of apoptosis, autophagy, excitotoxicity and oxidative stress * Protein aggregation and neurodegeneration; protein misfolding, ubiquitination, the the proteasome. * Transmissability and infectivity-the prion hypothesis. * Translational medicine, how close are we to finding novel drugs to treat NDD?  
Key skills provided by module:This course will provide all who take part with a detailed and up to date knowledge of the molecular and genetic basis of several human neurodegenerative diseases. It will additionally enable students to critically assess the contemporary literature on this topic, and provide insights into future directions for innovative therapies.  
Module timetable:https://cmis.adcom.ucl.ac.uk:4443/timetabling/moduleTimet.do?firstReq=Y&moduleId=ANAT3028 
Module assessment:Unseen three-hour written examination 100.00%. 
Notes:Runs in Term 1, Block E. 
Taking this module as an option?: 
Link to virtual learning environment(registered students only)https://moodle.ucl.ac.uk/course/view.php?id=6637 
Last updated:2012-08-16 13:51:20 by