Overview

This three-day online course explores how to use experimental design techniques to rapidly understand and optimise bioprocess performance.

You'll learn how experimental design and small scale experimental models can underpin Quality by Design (QbD) approaches.

You'll also get hands-on training on Design of Experiments (DoE) software.

This course is for laboratory scientists and engineers and managers.

Course content and structure

Teaching will be online, over three consecutive days. You'll be taught in small classes, with an emphasis on interactive problem solving and case studies.

Each day will cover the following topics:

Day 1

• Introduction to module and design of experiments
• Introduction to experimental design techniques and software
• Case studies: analytical method validation (one-factor-at-a-time vs design of experiments)
• Case Study: analytical method development
• Industrial analytical method validation using DoE

Day 2

• Screening and optimisation of microbial fermentations
• Case study: fermentation process screening
• Case study: fermentation process optimisation and scaleup
• Protein refolding, stabilisation and formulation: structural and environmental parameters that impact on maintenance and stabilisation of protein structure and activity
• Development of a QbD pharmaceutical production process using sequential DoE methodology

Day 3

• Case study: primary product recovery by microfiltration
• The application of factorial design in high throughput scale-down bioprocess development: examples in fermentation and cell culture
• DoE and the multivariate consequences for bioprocess development
• Discussion forum

Who the course is for

The course is for anyone involved in bioprocess development and optimisation including:

• bioprocess applications specialists
• hands-on bioprocess scientists and engineers
• research managers and consultants

Learning outcomes

After completing this course you should be able to:

• generate appropriate experimental designs within fixed research budgets and timescales
• ensure analytical methods can be validated and provide reliable data for process evaluation
• rapidly screen and optimise different fermentation media and operating conditions
• obtain the highest yield of active product throughout your downstream process sequence
• understand the relationship between DoE and QbD

Costs and group bookings

The standard price for this course is £1,750.

Special prices are available for groups and SMEs. Contact mbi-training@ucl.ac.uk for more information.

Modular Training for the Bioprocess Industries

The award-winning MBI programme is a series of UCL-accredited short courses for people working in the bioprocessing industry. It's designed and delivered in collaboration with over 70 industrial experts.

The programme provides flexible professional development training. You can choose to take standalone courses or combine them for a Certificate, Diploma or Master's qualification. It complements in-house training by providing broader perspectives for more informed decision-making.

Courses have so far been delivered to over 900 individuals from more than 300 companies, 30% of which are non-UK, demonstrating its strong international impact.

MBI plays a central role in the department's knowledge-transfer activities. This ensures that cutting-edge research is undertaken to capture the value of integrating engineering with complex and fast-moving biology, which helps keep the global industry ahead in manufacturing.

Benefits of MBI

By attending an MBI course, you'll:

• benefit from knowledge transfer and upskilling in core bioprocessing fundamentals and trends in industry
• gain a deeper understanding of process options and engineering constraints
• acquire the tools to optimise process performance and economics
• learn about the latest technical and regulatory developments
• have access to cutting edge research methodologies
• network with sector leaders and subject matter experts
• increase your flexibility, motivation, creativity and professional status

Further information

There is more information about the MBI on the Department of Biochemical Engineering's website. If you have questions about fees or how to combine courses for a specific qualification, please email mbi-training@ucl.ac.uk

Course team

Dr Stephen Goldrick - Module Leader

Stephen is Lecturer/Associate Professor in Digital Bioprocess Engineering in the Department of Biochemical Engineering at UCL.

Course information last modified: 30 Nov 2022, 16:01