Lunch hour lectures repository Autumn 2008
- 7 October 2008: Is Human Evolution Over?
- 9 October: A Tale of Two Churches
- 14 October: How Does My Brain Hear Your Voice?
- 16 October: Voice of God
- 21 October: The Zen of Running
- 23 October: UrbanBuzz - Building Sustainable Communities
- 28 October: Darwin, Microbes and the Increasing Incidence of Chronic Inflammatory Diseases (UNFORTUNATELY DUE TO TECHNICAL PROBLEMS, WE WERE UNABLE TO RECORD THIS LECTURE AND IT WILL NOT BE AVAILABLE TO VIEW ONLINE)
- 30 October: What's New in Magnetic Healing?
- 11 November: The Northern Utopia: What is Distinctive About the Nordic Countries
- 13 November: Do We Need a British Bill of Rights and a Written Constitution?
- 18 November: TRIM5, Human Immunodeficiency Virus (HIV) and the Red Queen
- 20 November: Rescuing the Past: Prayer Books, Parchment and Multi-Spectral Imaging
- 25 November: The Secret of Man's Red Fire
- 27 November: From 'Grey Goo' to Nanomedicine
- 2 December: Earthquake Vulnerability: An Engineer's Perspective With a Difference
- 4 December: Stemming Vision Loss With Stem Cells - Seeing is Believing
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18 November: TRIM5, Human Immunodeficiency Virus (HIV) and the Red Queen
18 May 2007
Dr Greg Towers – UCL Immunology & Molecular Pathology
Retroviruses such as HIV have been infecting mammals for millions of years. Host species have therefore evolved ways to protect themselves. Virus counter-evolution leads to an evolutionary arms race, described by the Red Queen hypothesis. An important defence is provided by proteins called restriction factors, such as TRIM5, which inactivate incoming viral infection and provide symptom free immunity. It seems the best way to avoid infection is to block viral replication early on. But why do humans contract HIV? This lecture will introduce the concept of innate antiviral restriction factors and consider how viruses escape them to cause disease with a focus on HIV/AIDS.
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