Leukaemia Cytogenetics at the Royal Free

The molecular cytogenetics laboratory at the Royal Free NHS Trust is at the centre of a dynamic North Central London and West Essex Board initiative to embody the best of the latest techniques in leukaemia cytogenetics where blood and bone marrow samples from leukaemia patients come for analysis.

Building on a track record of innovative research, Dr Ellie Nacheva and her team offer cytogenetic analytical tests from G-banded metaphase analysis, through a wide range of FISH tests to the latest in high resolution genomic array screening.

Review

Publications and Posters from recent conferences relating to

• Significance Analysis of Genomic Array Data
• New mechanism of TKI Resistance in CML
• FISH mapping of Philadelphia negative CML
• Array CGH study of TP53 aberrations as part of a complex karyotype
• TKI therapy related AML with evi1 Rearrangement and -7 in Ph(-) CML
• Amplification of the 9q34.12 region of chromosome 9 in BC CML
• Deletions of P16 and Ikaros genes in Lymphoid CML BC
• Impact of peripheral blood stem cell donation
• HHV6 chromosomal integration

Dr Ellie Nacheva MD PhD FRCPath Royal Free and University College School of Medicine

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