At the London Fertility Centre I was working on ways to help identify the best embryo for transfer. When I initially started work on PGD (Wellcome grant) I used FISH to examine chromosome arrangements in human embryos and was the first to report the high levels of mosaicism that have now been observed by many other groups internationally.
I am principal investigator of Genetics, Embryology and IVF Group and person responsible for the HFEA Research Licence. I am head of research and development at the Centre for Reproductive and Genetic Health, UCLH. Publication list (link).
My team is investigating factors that affect preimplantation development, using both human and mouse embryos, and ways of determining the healthiest gametes and embryos. We have been working on comparisons of in vitro and in vivo development, chromosome analysis, DNA fragmentation, epigenetics, metabolomics, culture media and time lapse video.
- Research Team in PGD
- Mechanism of mosaicism in preimplantation embryos
- Whole genome amplification and microarray methods to use on single human embryonic cells
- DNA fragmentation and aneuploidy in sperm
- Methylation patterns of preimplantation embryos
- Metabolomics of the human embryo and relation to aneuploidy
- Culture media used in IVF
- Analysis of development of mouse and human embryos using time lapse imaging
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