prof joyce harper
- UCL Centre for PGD, IWH
- UCL, 86-96 Chenies Mews
- WC1E 6HX
- Professor of Human Genetics and Embryology
- Reproductive Medicine
- Inst for Women's Health
Principal investigator of UCL Centre for PG & D and person responsible for the HFEA Research Licence and head of research and development at the Assisted Conception Unit, UCLH. UCL Centre for PG & D covers a range of research interests in preimplantation genetics, ranging from DNA damage and aneuploidy in sperm to methylation patterns in human embryos. At the London Fertility Centre I was working on ways to help identify the best embryo for transfer. When I initially started work on PGD (Wellcome grant) I used FISH to examine chromosome arrangements in human embryos and was the first to report the high levels of mosaicism that have now been observed by many other groups internationally. I have also been trying to elucidate the mechanism of these abnormalities, which includes abnormalities in cell cycle checkpoints. This work has been sponsored by an MRC JREI Equipment Grant, Tommy's Campaign and UCL Special Trustees. Our Wellbeing grant was used to apply these techniques to study human oocytes. I am principal investigator of UCL Centre for PG & D and person responsible for the HFEA Research Licence. I am head of research and development at the Assisted Conception Unit, UCLH. See publication list (link to this page). Main topics: * Mechanism of mosaicism in preimplantation embryos * Whole genome amplification and microarray methods to use on single human embryonic cells * DNA fragmentation and aneuploidy in sperm * Methylation patterns of preimplantation embryos * Metabolomics of the human embryo and relation to aneuploidy * All aspects of infertility related research
- Investigation into human preimplantation development
Testicular histopathology as a predictor of a positive sperm retrieval in men with non-obstructive azoospermia
Investigation of gene expression profiles before and after embryonic genome activation and assessment of functional pathways at the human metaphase II oocyte and blastocyst stage.
The effect of GM-CSF on murine embryo development, aneuploidy, DNA fragmentation and morphokinetic parameters analysed using EmbryoScopeo
Processes involved in assisted reproduction technologies significantly increase sperm DNA fragmentation and phosphatidylserine translocation
Detection of aneuploidy by array comparative genomic hybridization using cell lines to mimic a mosaic trophectoderm biopsy.
1988PhDDoctor of PhilosophyKing's College London
1984BScBachelor of ScienceUniversity of London
I read Biochemistry at Queen Elizabeth College from 1981-1984 and obtained a 2/1. I joined the pharmacology department at Kings College London where I studied a PhD under the supervision of Professor John Littleton looking at the effects of alcohol on catecholamine release from adrenal chromafin cells. I started working in IVF in 1987, initially spending a few months at the Hallam Medical Centre and then moving onto work with Professor Ian Craft at the London Fertility Centre. I designed new IVF labs at Cozens House, 112A Harley Street and in Dubai.
In 1992 I joined the PGD team at the Hammersmith Hospital performing clinical biopsies and FISH diagnosis as well as undertaking research into chromosome abnormalities of human embryos. In 1993 I started a joint project with the Hammersmith Hospital and University College London. In 1997 I designed (with Professor Joy Delhanty and Professor Charles Rodeck) the first of my MSc programmes at UCL that I direct (Prenatal Genetics and Fetal Medicine) and in 2002 I developed a second MSc programme (Reproductive Science and Womens’ Health).
My current roles include being a Reader in Human Genetics and Embryology at UCL, Principal Investigator for Reproductive Genetics as part of UCL Centre for PGD (www.ucl.ac.uk/PGDthe Centre for Reproductive and Genetic Health, Education Lead for the Institute for Women’s Health, Chair of UCLs Education Domain, Faculty Graduate Tutor and Institute Graduate Tutor. I have had many senior roles in ESHRE, including helping establish the ESHRE PGD Consortium. I also has several roles in the HFEA and am currently on the Board of the British Fertility Society. For further information see www.joyceharper.com. In 2014 I set up a company providing global hands on training in clinical PGD and Embryology (Embryology and PGD Academy).
- All aspects of early human development and infertility
- Fluorescence microscopy techniques
- Genetic screens
- Image analysis
- In vitro models
- Preimplantation genetic diagnosis
- Reproductive biology
Page last modified on 23 jul 12 12:14