The cost effectiveness of assays of genetic markers for antibiotic resistance in tuberculosis

This review will answer key questions on the clinical impact and cost effectiveness of the use and role of different assays identifying genetic markers associated with multidrug and extensively drug resistant TB in patients with tuberculosis across the UK through

a. Systematic review of the published and grey literature
b. Transmission dynamic model to determine the implications of secondary transmission.
c. Decision analytic health economic model of various screening strategies (including different commercial/in house assays, geographically dispersed versus centralised models of service and targeting of rapid testing at various high-risk sub-groups)

Review team

Professor Francis Drobniewski, Queen Mary, University of London
Dr Ibrahim Abubakar, University College London
Dr Mark Jit, Public Health England
Dr Peter White, Imperial College London/Public Health England
Dr Marc Lipman, University College London
Dr Joanne Lord, Brunel University
Dr Andre Charlett, Public Health England
Dr Nicola Casali, Queen Mary, University of London

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