This is a community study of behavioral & biological determinants of transmission to inform seasonal & pandemic planning.
The study commenced in 2006, and is funded by the Medical Research Council (MRC). Households distributed across England have been recruited through the MRC General Practice Research Framework (GPRF). We have followed the cohort through several influenza seasons, and defined cases of influenza infection through pre-and post season serology and divided them into symptomatic and asymptomatic cases based on symptom diaries. Viral shedding has been identified through self-submitted nasal swabs for RT-PCR identification of influenza, and nformation on patient contact patterns has been collected, providing empirical data to inform models of pandemic and seasonal influenza transmission. In nested case control studies, pre and post season blood samples from patients with confirmed influenza and controls have been used to assess the T cell response to influenza using a validated interferon-gamma elispot assay. External collaborators include colleagues at University of Oxford and the Health Protection Agency.
Andrew Hayward is the principal investigator. The study team also includes Faiza Tabassum, Ellen Fragaszy, Fatima Wurie and Cherry Constantine.
Flu Watch/MOSAIC collaborative study
UCL Study Coordinator – Fatima Wurie
MOSAIC (Mechanisms of Severe Acute Influenza Consortium) is a UK-wide consortium of research groups studying influenza pathogenesis in patients hospitalised with severe H1N1 disease during the pandemic. It is a MRC/Wellcome Trust funded study led by Chief Investigator Professor Peter Openshaw, Imperial College London.
Flu Watch are collaborating with MOSAIC in comparing the genetic profiles of subjects mildly infected with H1N1 and seasonal strains with that of those who were severely ill and hospitalised or died as a result of influenza infection. It is anticipated that this collaborative study will provide useful insights into understanding genetic determinants of severe infection.
Click here to go back to the list of studies in the Centre for Infectious Disease Epidemiology.
Page last modified on 16 may 12 12:22