Imaging     Angiogenesis     Retinal Pigment Epithelial     Treatment    

Retinal Pigment Epithelial (RPE) Cell Failure

RPE cells are essential for the maintenance of a healthy retina, and anything that compromises their functional integrity can have deleterious knock-on effects on vital activities such as phagocytosis of rod outer segments or maintenance of the blood retinal barrier. We currently have research programmes investigating the following aspects of RPE cell function:
• Regulation of phagocytosis of rod outer segments
• Differentation of retinal progenitor and stem cells into RPE cells
• Control of melanosome biogenesis and function
• Regulation of RPE cell proliferation and barrier function
• Derivation of RPE cells for cell replacement therapies
• Circadian regulation of gene expression
• New models of regulatable gene expression in the RPE
• Targeting RPE cells for gene therapy
• The host retinal response to RPE cell transplantation

IO researchers working in this area:
Professor Robin Ali
Dr Maria Balda
Professor Pete Coffey
Dr Marcus Fruttiger
Dr Clare Futter
Professor John Greenwood
Dr Imre Lengyel
Professor Steven Moss

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