Corneal Transplant     Infection     Allergic Eye Disease    


Intraocular infection has devastating consequences on the eye. Many affected patients lose vision to the level of legal blindness. This is despite antibiotic treatment with intraocular and systemic antibiotics to which the cultured organisms are sensitive to at least one of the antibiotics used at least in vitro. The most common organisms involved are coagulase negative staphylococci, and clinically, there is effective antibiotic resistance. Using intraocular isolates taken from infected eyes, in which all have antibiotic sensitivities and the clinical outcome of the infection in the patient is known, we are looking at novel ways in which antibiotic resistance may be reduced. This includes determining the effect of oxygen gradient and pH on antibiotic sensitivity, looking at factors involved in adherence of the organisms and how this influences antibiotic sensitivity of antibiotics both singly and in combinations. Important virulence factors in the organisms themselves are being correlated with in vitro antibiotic resistance and clinical outcome.

IO researchers working in this area:
Professor Sue Lightman

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