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Eye Therapy News

2 Lazy 2 Run? We’re biking it for blood cancer!

Fri, 29 Aug 2014 09:30:05 +0000

  On Sunday 31 August a group of not so elite athletes from the Gene and Cell Therapy group will be taking part in the London Bikeathon 2014 to raise funds for Leukaemia & Lymphoma Research. The 2 Lazy 2 Run CC will be cycling 52 miles – that’s more than a marathon, no mean feet […]

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The Art of Eyes

Thu, 07 Aug 2014 14:23:19 +0000

The eye is an object of great beauty as shown by the Ophthalmologist in their July/August 2014 issue. This month’s issue features a photo essay called The Art of the Eyes and includes examples of the work from a number research labs capturing the complex and beautiful detail of the eye and its cells. The essay includes images […]

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In memoriam

Tue, 05 Aug 2014 16:02:34 +0000

Dr Yoshiki Sasai (1962 – 2014) It is with great sadness today that we remember and pay tribute to our collaborator Dr Yoshiki Sasai. Yoshiki was a world leading stem cell researcher and Deputy Director of the Riken Center for Developmental Biology in Kobe, Japan. Through his hard work and dedication over many years, Yoshiki […]

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International Clinical Trials Day: Our Work in Summary

Tue, 20 May 2014 15:03:41 +0000

Introduction Today, 20 May 2014, is International Clinical Trials Day. This landmark day remembers the pioneering work of James Lind a Scottish naval physician who, in the 1700s, conducted the first controlled clinical study that identified that citrus fruit (containing Vitamin C) was effective in treating scurvy. Each year, a number of organisations mark this […]

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Dr. Adam Dubis: A Researcher With a Vision for Optical Imaging

Fri, 16 May 2014 10:37:16 +0000

This month our own Dr Adam Dubis is profiled as one of the ‘People Behind the Science’. Adam is a Research Associate here at the UCL Institute of Ophthalmology and is the Advanced Human Retinal Imaging Specialist at Moorfields Eye Hospital NHS Foundation Trust. Listen to how Adam got to where he is today and […]

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Dr. Rachael Pearson - current research projects

1) Defining new strategies to restore cone-mediated vision. We have demonstrated that it is possible to restore vision mediated by rods but humans rely heavily upon cones for vision in daylight and colour-vision. For this reason, we aim to define new strategies for the restoration of cone-mediated vision by transplantation.

2) Determine the mechanisms of migration utilized by both rod and cone precursors in normal development and following transplantation. By understanding how the small proportion of cells transplanted manage to migrate into the recipient retina, we should be able to find ways to manipulate this migration and drive more cells into the recipient retina.

3) Determine strategies for breaking down barriers within the recipient retina. We have recently examined transplantation efficiency in a variety of models of retinal degeneration and found that disease type has a major impact on outcome (Barber et al., in review). On going work in my group aims to identify factors within the degenerating retina that impede (or enhance) transplanted cell integration and find ways to manipulate them to improve transplantation outcome (West et al., 2012; Pearson et al., 2010; West et al., 2008)

4) Determine whether purinergic signalling as an evolutionarily restricted signalling mechanism in the control of retinal stem cell proliferation. Unlike lower vertebrates, the mammalian retina lacks the ability to generate. Understanding the mechanisms behind these differences is crucial to knowing whether it might be possible to stimulate the mammalian retina to repair itself. We believe that the presence or absence of purinergic signaling may be important in determining this capability.

Techniques used in the lab: multi-photon, confocal and fluorescence microscopy, stem cell culture, calcium imaging, proliferation assays, viral vector production, molecular biology, transplantation, RNAi, multielectrode array recordings, electroretinogram recordings, intrinsic imaging of visual cortex, behavioural tests of vision.

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