Gene and cell therapies for age-related macular degeneration (AMD) and diabetic eye disease

Gene therapy to control the damaging growth of blood vessels

Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. JWB Bainbridge, A Mistry, M De Alwis, E Paleolog, A Baker, AJ Thrasher and RR Ali Gene Ther. 2002; 9 (5): 320-326

EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV. KS Balaggan, K Binley, M Esapa, Re MacLaren, S Iqball, Y Duran, RA Pearson, O Kan, SE Barker, AJ Smith, JWB Bainbridge, S Naylor and RR Ali Gene Ther. 2006; 13 (15):1153-1165

Models of disease

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. UF Luhmann, CA Lange, S Robbie, PM Munro, JA Cowing, HE Armer, V Luong, LS Carvalho, RE MacLaren, FW Fitzke, JW Bainbridge and RR Ali PLoS One 2012; 7 (4): e35551

The Drusen-like phenotype in aging Ccl2 knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. UF Luhmann, S Robbie, PM Munro, SE Barker, Y Duran V Luong, FW Fitzke, J Bainbridge, RR Ali & R MacLaren. Invest Ophthalmol Vis Sci. 2009; 50 (12): 5934-43

Von Hippel-Lindau protein in the RPE is essential for the normal ocular growth and vascular development. CAK Lange, UFO Luhmann, FM Moway, EL West, H Sayed, AJ Smith, JC Sodewn, PH Maxwell, RR Ali and JW Bainbridge Development 2012; 139 (13): 2340-50

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. FM Mowat, UF Luhmann, AJ Smith, C Lange, Y Duran, S Harten, D Shukla, PH Maxwell, RR Ali and JW Bainbridge. PLoS One 2010; 5 (6): e11103

Clinical disease mechanisms

Intraocular oxygen distribution in advanced poliferative diabetic retinopathy.
CA Lange, P Stavrakas, UF Luhmann, DJ de Silva, RR Ali, ZJ Gregor & JW Bainbridge Am J Ophthalmol. 2011;152 (3): 406-412

Page last modified on 22 oct 12 15:23


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