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Eye Therapy News

Professor Ali honoured for his contribution to research into retinal disease

Mon, 08 Sep 2014 12:27:36 +0000

              Professor Robin Ali, PhD, Professor of Human Molecular Genetics and Head of the Department of Genetics, UCL Institute of Opthalmology has been awarded the Pioneer Award for his work in proof-of-concept studies that have demonstrated the feasibility of using gene therapy and cell transplantation to treat dysfunction and degeneration of the cells […]

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Achromatopsia might not be as progressive as previously thought

Mon, 08 Sep 2014 11:17:16 +0000

A recent publication from the UCL Institute of Ophthalmology, Moorfields Eye Hospital, and the Medical College of Wisconsin indicates that for the majority of people with achromatopsia, the condition may not be as progressive as previously suggested. Data from this study by Aboshiha et al. demonstrated that for the majority of people with achromatopsia (a […]

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2 Lazy 2 Run? We’re biking it for blood cancer!

Fri, 29 Aug 2014 09:30:05 +0000

  On Sunday 31 August a group of not so elite athletes from the Gene and Cell Therapy group will be taking part in the London Bikeathon 2014 to raise funds for Leukaemia & Lymphoma Research. The 2 Lazy 2 Run CC will be cycling 52 miles – that’s more than a marathon, no mean feet […]

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The Art of Eyes

Thu, 07 Aug 2014 14:23:19 +0000

The eye is an object of great beauty as shown by the Ophthalmologist in their July/August 2014 issue. This month’s issue features a photo essay called The Art of the Eyes and includes examples of the work from a number research labs capturing the complex and beautiful detail of the eye and its cells. The essay includes images […]

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In memoriam

Tue, 05 Aug 2014 16:02:34 +0000

Dr Yoshiki Sasai (1962 – 2014) It is with great sadness today that we remember and pay tribute to our collaborator Dr Yoshiki Sasai. Yoshiki was a world leading stem cell researcher and Deputy Director of the Riken Center for Developmental Biology in Kobe, Japan. Through his hard work and dedication over many years, Yoshiki […]

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Gene and cell therapies for age-related macular degeneration (AMD) and diabetic eye disease

Gene therapy to control the damaging growth of blood vessels

Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. JWB Bainbridge, A Mistry, M De Alwis, E Paleolog, A Baker, AJ Thrasher and RR Ali Gene Ther. 2002; 9 (5): 320-326

EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV. KS Balaggan, K Binley, M Esapa, Re MacLaren, S Iqball, Y Duran, RA Pearson, O Kan, SE Barker, AJ Smith, JWB Bainbridge, S Naylor and RR Ali Gene Ther. 2006; 13 (15):1153-1165

Models of disease

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. UF Luhmann, CA Lange, S Robbie, PM Munro, JA Cowing, HE Armer, V Luong, LS Carvalho, RE MacLaren, FW Fitzke, JW Bainbridge and RR Ali PLoS One 2012; 7 (4): e35551

The Drusen-like phenotype in aging Ccl2 knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. UF Luhmann, S Robbie, PM Munro, SE Barker, Y Duran V Luong, FW Fitzke, J Bainbridge, RR Ali & R MacLaren. Invest Ophthalmol Vis Sci. 2009; 50 (12): 5934-43

Von Hippel-Lindau protein in the RPE is essential for the normal ocular growth and vascular development. CAK Lange, UFO Luhmann, FM Moway, EL West, H Sayed, AJ Smith, JC Sodewn, PH Maxwell, RR Ali and JW Bainbridge Development 2012; 139 (13): 2340-50

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. FM Mowat, UF Luhmann, AJ Smith, C Lange, Y Duran, S Harten, D Shukla, PH Maxwell, RR Ali and JW Bainbridge. PLoS One 2010; 5 (6): e11103

Clinical disease mechanisms

Intraocular oxygen distribution in advanced poliferative diabetic retinopathy.
CA Lange, P Stavrakas, UF Luhmann, DJ de Silva, RR Ali, ZJ Gregor & JW Bainbridge Am J Ophthalmol. 2011;152 (3): 406-412

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