EyeTherapy Blog News

UCL researchers solve a major riddle of retinal degeneration research!

Mon, 26 Jan 2015 10:11:36 +0000

Today a paper published in Nature Communications from the Gene and Cell Therapy Group at the UCL Institute of Ophthalmology has shed light on why, until now, it has not been possible to effectively restore vision in rd1 mice – the world’s major model for retinitis pigmentosa (RP). The rd1 mouse is a model of […]


Professor Ali honoured for his contribution to research into retinal disease

Mon, 08 Sep 2014 12:27:36 +0000

              Professor Robin Ali, PhD, Professor of Human Molecular Genetics and Head of the Department of Genetics, UCL Institute of Opthalmology has been awarded the Pioneer Award for his work in proof-of-concept studies that have demonstrated the feasibility of using gene therapy and cell transplantation to treat dysfunction and degeneration of the cells […]


Achromatopsia might not be as progressive as previously thought

Mon, 08 Sep 2014 11:17:16 +0000

A recent publication from the UCL Institute of Ophthalmology, Moorfields Eye Hospital, and the Medical College of Wisconsin indicates that for the majority of people with achromatopsia, the condition may not be as progressive as previously suggested. Data from this study by Aboshiha et al. demonstrated that for the majority of people with achromatopsia (a […]


Gene therapy for uveitis

Uveitis is a leading cause of sight loss amongst those of working age. Find out about how you can support our work and help develop effective therapies.

Uveitis is a group of conditions in which the immune system attacks the body's own cells, leading to damaging inflammation and loss of sight. The eye's local immune system is normally tightly regulated by a balance of cells and molecules that prevent large-scale inflammation; caused by many different triggers depending on whether the front of the back of the eye is affected, uveitis results from a failure of this tight regulation. 

Uveitis can give rise to inflammation in the blood vessels serving the back of the eye (left), white spots known as keratic precipitates forming on the inner surface of the cornea (right), and many other forms of inflammatory damage to the eye

Uveitis is a common condition for which existing treatments have limitations - they are short-acting and are often systemically delivered, and chronic use can have significant side-effects. We are therefore developing longer-acting, locally-administered treatments based on viral gene therapy.

We have shown that delivering genes that help control the immune system locally in the eye can prevent the most damaging types of inflammation seen in models of uveitis, and are improving the effectiveness of gene therapy for uveitis through ongoing studies.

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