Gene and Cell Therapy Group
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Gene therapy for corneal disease
Damage to the cornea can cause sight loss that only transplants can reverse - but these transplants often fail. Find out how you can support our work and help develop effective therapies.
cornea, the transparent window at the front of the eye, can become
damaged as a result of genetic conditions such as Fuchs endothelial
dystrophy, complex conditions like keratoconous, and injury. In some
cases this damage requires a corneal transplant to repair, which are
subject to both immune rejection and graft failure. We are developing ways
of improving the quality of corneas used for transplant, and reducing the chances of immune rejection, using
Our aim is to take human corneas that have been donated but are of unsuitable quality for organ transplantation, infect them temporarily with a viral vector carrying a gene that improves the cornea's health, then proceed with the transplant as usual.
We are currently focussing on delivering genes to human corneal cells in culture using lentiviral and AAV-based vectors, with the aim to improve corneal transplant quality.
A common cause of cornea transplant failure is rejection of the graft cornea by the host immune system
We are developing strategies to help reduce the likelihood of immune rejection, seeking to deliver genes that would regulate the host immune response to the transplant.
Page last modified on 07 nov 12 17:04