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Eye Therapy News

The Art of Eyes

Thu, 07 Aug 2014 14:23:19 +0000

The eye is an object of great beauty as shown by the Ophthalmologist in their July/August 2014 issue. This month’s issue features a photo essay called The Art of the Eyes and includes examples of the work from a number research labs capturing the complex and beautiful detail of the eye and its cells. The essay includes images […]

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In memoriam

Tue, 05 Aug 2014 16:02:34 +0000

Dr Yoshiki Sasai (1962 – 2014) It is with great sadness today that we remember and pay tribute to our collaborator Dr Yoshiki Sasai. Yoshiki was a world leading stem cell researcher and Deputy Director of the Riken Center for Developmental Biology in Kobe, Japan. Through his hard work and dedication over many years, Yoshiki […]

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International Clinical Trials Day: Our Work in Summary

Tue, 20 May 2014 15:03:41 +0000

Introduction Today, 20 May 2014, is International Clinical Trials Day. This landmark day remembers the pioneering work of James Lind a Scottish naval physician who, in the 1700s, conducted the first controlled clinical study that identified that citrus fruit (containing Vitamin C) was effective in treating scurvy. Each year, a number of organisations mark this […]

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Our research programme

Clinical trials of gene and cell therapy for sight loss


We are currently conducting two ground-breaking clinical trials:

The world's first gene therapy trial in the eye, testing the safety and efficacy of delivering the RPE65 gene to the eyes of patients with Leber congenital amaurosis.

Europe's first trial testing the safety of transplanting stem cell-derived retinal cells into the eyes of patients with Stargardt disease.

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A pipeline of gene and cell therapies for sight loss

Gene and cell therapies for inherited sight loss

We are developing a pipeline of potential therapies for which we have established proof-of-concept, showing that gene therapy and the transplantation of retinal cells derived from stem cells are effective at restoring vision in small and large animal models of inherited retinal degeneration.

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Gene and cell therapies for age-related macular degeneration (AMD)

We are investigating novel treatments for AMD that build on our understanding of the causes of sight loss in this complex disease. Our programme of laboratory research into AMD covers the mechanisms of sight loss and the development of both gene and cell therapy.

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Gene therapy for diabetic eye disease


Diabetic eye disease, including diabetic retinopathy and maculopathy, is the leading cause of vision loss amongst those with diabetes.

We have used several well-established animal models of disease to further our understanding of factors that contribute to vision loss in these diseases, with a view to identifying drug targets and ways to intervene using gene and cell therapy.

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Gene therapy for uveitis


We have established proof-of-concept that the delivery of genes encoding anti-inflammatory proteins can reduce damage to the retina in models of uveitis, and are developing new and more effective ways of treating this common cause of sight loss.

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Gene therapy for corneal disease


We are developing ways of improving the quality of corneas used for transplant, and reducing the chances of immune rejection, using gene therapy.

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Page last modified on 11 sep 12 14:23