Early Detection     Genetics     Treatment

Early Detection

Glaucoma is the second most common cause of blindness in the world and the leading cause of irreversible blindness. There are two forms, with primary open-angle glaucoma predominating in Europe and North America and primary angle-closure glaucoma most common in Asia. Increased intraocular pressure (IOP) is a major risk factor and although IOP can be reduced with current medical technology, progressive visual loss can still occur. Surgery can be the most effective treatment but scarring reduces beneficial effects – though we have pioneered several treatments to inhibit surgical scarring. We are developing new methods to detect chronic glaucoma before the onset of vision loss, using imaging and psychophysical tests, and we are initiating innovative screening programmes for angle-closure disease. We are also looking at non-IOP strategies for glaucoma, and using novel methods for assessing their efficacy. Finally with colleagues in Moorfields, we are investigating the genetic basis of the disease.

IO researchers working in this area:

Professor Shomi Bhattacharya
Dr Francesca Cordeiro
Dr Steven Dakin
Professor Fred Fitzke
Dr Paul Foster
Professor Peng Khaw

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