Single Gene Disease        Complex Disorders       Evolutionary Genetics    

Complex Disorders

For many common diseases in humans, the causative factors are numerous and may include diet and life style. In most cases, there is also a genetic component responsible for altering susceptibility to disease. Inheritance is therefore not straightforward, and the likelihood of disease arises from the interaction of these genetic and environmental factors. Current studies in this area include age-related macular degeneration (AMD). AMD is the major cause of poor vision in people over the age of 60. Risk factors include smoking, obesity, ethnicity, family history and gender, with women more at risk than men. A number of genetic risk factors have now been identified but others may exist. Ongoing work includes both the generation of a large panel of patients in which the disease has been carefully assessed and studies on the development of the disorder in model systems.

IoO researchers working in this area:

Professor Robin Ali
Professor Shomi Bhattacharya
Professor Alan Bird
Professor Pete Coffey
Professor John Greenwood
Professor Phil Luthert
Professor Steve Moss
Professor Tony Moore
Dr Andrew Webster
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