Imaging     Angiogenesis     Retinal Pigment Epithelial     Treatment    


The most severe complication in AMD is caused by abnormal blood vessel growth. In these patients, vessels which are normally separated from the retina by the RPE penetrate this barrier and grow into the photoreceptor layer of the retina. This occurs almost exclusively in the centre of the visual field (the area with the highest acuity) and eventually causes irreversible blindness in this part of the retina. It is not known what starts the aberrant vessel growth but it is known that there must be specific signals to which the vessels respond. We are therefore studying the signals that can induce or stop the growth of blood vessels. Understanding the molecular nature and the genetic basis of these signalling mechanisms will allow us in the future to interfere with them and to stop blood vessel growth in AMD.

IO researchers working in this area:
Dr Marcus Fruttiger
Professor John Greenwood
Dr Christiana Ruhrberg

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