Corneal Transplant     Infection     Allergic Eye Disease    

Allergic Eye Disease

Chronic inflammation impacts on tissue-resident cells. There are several chronic inflammatory diseases affecting the eye in which the immune cells themselves mediate damage to the ocular tissues via secretion of cytokines (soluble factors), as found in uveitis and in chronic allergic eye disease. We have been investigating the patterns of cytokines present in ocular fluids (aqueous humor, vitreous, tears) and in the inflammatory cells present in the tissues and disease-specific profiles are beginning to emerge. Culture systems have been established to identify the pathways involved during immune cell interactions with ocular cells (retinal pigment epithelial and endothelial cells and conjunctival mast cells, fibroblasts and epithelial cells) both at the molecular and cellular level.

A major goal is to improve therapeutic options for these chronic diseases since current immunosuppressive treatments have serious side effects when taken long term, especially in the eye. Several trials are underway in this area.

IO researchers working in this area:
Dr Virginia Calder
Professor John Greenwood
Professor Sue Lightman
Dr Patric Turowski

You need to upgrade your Flash Player