Lipid and Protein Synthesis     Cytoskeleton     Epithelial     Endothelial    

Endothelial Cell Biology

Endothelial cells form the blood vessels that provide oxygen and nutrients to all the cells in the body. Endothelial cells must undergo controlled migration so that vessels grow in the right place and must there form a barrier that allows controlled permeability to both molecules and cells. We are investigating the regulation of vascular endothelial cell proliferation, migration, specialisation and survival, which will aid in the identification of targets for therapeutic strategies aimed at preventing the excessive new vessel growth that occurs in several eye diseases. Identifying the molecular mechanisms that regulate barrier function of endothelial cells, in particular factors regulating the migration of inflammatory cells across endothelial cell monolayers, will lead to a better understanding of the pathogenesis of inflammation and how inflammatory eye disease can be treated.

IO researchers working in this area:

Dr Maria Balda
Professor John Greenwood
Professor Karl Matter
Professor Steven Moss
Dr Christiana Ruhrberg
Dr Patric Turowski

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