Archive of IoN NEWS

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Major initiative in understanding synaptic basis of neuropsychiatric disease

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Prof James Rothman

James Rothman (Nobel Prize 2013) will shortly establish a laboratory at the Institute of Neurology under the Yale-UCL collaboration as part of a major initiative to understand the synaptic basis of neuropsychiatric disease. His discovery of the molecular machinery underlying neurotransmitter release from synaptic vesicles opens a new window on the genetic basis of neuropsychiatric diseases, mental health, migraine, epilepsy and movement disorders. He will be joined by James Jepson from Thomas Jefferson University, who will establish a laboratory using fruit flies to model neuropsychiatric diseases. In parallel, Dennis Kaetzel (Sir Henry Wellcome Fellow, UCL and Oxford) is applying the latest optogenetic and chemical-genetic methods to understand the circuit basis of schizophrenia. Institute researcher Dimitri Kullmann says, "These developments provide an important bridge from human genetics to circuit dysfunction, and promise to accelerate the pace of discovery of neurological and neuropsychiatric disease mechanisms at Queen Square".     

Visit to the Berlin School of Mind and Brain

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berlinpresentation2

For the second year in a row the Berlin School of Mind and Brain invited members of the Education Unit and four Institute of Neurology PhD students (Thomas Moens, Camilla Nord, Roman Praschberger and Svenja Espenhahn) to their annual poster presentations for their doctoral students, held on the 5th December 2013. The event was a huge success with much discussion and interest raised from all the posters presented, and the hospitality shown by everyone from the Berlin School of Mind and Brain was truly overwhelming. In particular we would like to thank Dr Inken Dose and Dr Dirk Mende for all their efforts in organising this trip, the poster presentations and for making the group feel so welcome. 

Institute of Neurology ranked as the world’s top institution for epilepsy research.

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UCL Institute of Neurology – in collaboration with the National Hospital of Neurology and Neurology and the Epilepsy Society - has been ranked as the world’s top institution for epilepsy research.

Predicting age at onset in SCA1 : does size matter?

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Research at the UCL Institute of Neurology, led by Paola Giunti, and the MRC National Institute for Medical Research, and published in the journal PloS Genetics, has shown how the length and the nature of gene repeat expansions affects spinocerebellar ataxia type 1 (SCA1).

UCL takes the lead with £8.5m funding for dementia research

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UCL has been awarded more than £8.5 million by the Economic and Social Research Council (ESRC) and the National Institute for Health Research (NIHR) to help tackle the challenges associated with dementia.

Secretary of State visits leading dementia research projects

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The Prime Minister today called for a global effort to tackle one of the greatest challenges of our time: dementia. UCL scientists, working with clinicians at the university's partner hospitals, are at the heart of the battle to treat the condition.

Riboflavin Treatment for Childhood onset Motor Neuron Disease

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A clinical and genetic study based at UCL Institute of Neurology and the Institute of Child Health, recently published in Brain, has used next generation sequencing to identify riboflavin transporter gene defects as the defective pathway in a severe form of childhood motor neuron disease. Children with these defects significantly respond to high dose riboflavin.

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