Alexander (Sasha) Kraskov

Cortical Control of Skilled Hand Function


Alexander Kraskov   a.kraskov{at}ucl.ac.uk

I am a Wellcome Trust Research Fellow in the lab of Prof Roger Lemon at the Sobell Department of UCL Institute of Neurology.

Before joining Roger’s lab I was a Swartz postdoctoral fellow at Sloan Swartz Center of Theoretical Neuroscience working with Prof. Christof Koch, Caltech. My research was focused on understanding whether LFPs potentials recorded in medial temporal lobe of human epileptic patients can be selective to categories of images presented to patients. We also investigated explicit encoding of multimodal percepts by single neurons in the human brain. The experiments were done in the lab of Dr. Itzhak Fried, UCLA.

I received my PhD degree (summa cum laude) from University of Wuppertal, Germany in the lab of Prof. Peter Grassberger based in John von Neumann Institute for Computing (full Phd text). I worked on methods for analysis of experimental (mostly physiological) data. We developed a new method for estimation of mutual information which was successfully applied to the clustering of data and to independent component analysis (ICA). The software and relevant papers are freely available here.

Current Projects

Recent Publications (Google Scholar Citations)

Vigneshwaran, G., Philipp, R., Lemon, R. N., and Kraskov, A. (2013) M1 corticospinal mirror neurons and their role in movement suppression during action observation, Current Biology. Pubmed, doi, free text.

Quallo, M.M.*, Kraskov, A.*, and Lemon, R.N. (2012) The activity of M1 corticospinal neurons during tool use by macaque monkey, J Neurosci, (32)48, 17235-17364 (*these authors contributed equally). Pubmed, free text.

Kraskov, A. (2012) The role of inhibition in action observation treatment, Developmental Medicine & Child Neurology, 54(9), 778. Pubmed, PMC free text.

Vigneswaran, G.*, Kraskov, A.*, and Lemon, R.N. (2011) Large identified pyramidal cells in macaque motor and premotor cortex exhibit “thin spikes”: implications for cell type classification, J Neurosci, 31(40), 14235-14242 (*these authors contributed equally).  Pubmed, PMC free textF1000 Evaluation (Factor 8/10)

Kraskov, A., Prabhu, G., Quallo, M.M., Lemon, R. N., and Brochier, T. (2011) Ventral Premotor-Motor Cortex Interactions in the Macaque Monkey during Grasp: Response of Single Neurons to Intracortical Microstimulation, J Neurosci, 31(24):8812-21. Pubmed, PMC free text.

Mormann F, Dubois J, Kornblith S, Milosavljevic M, Cerf M, Ison M, Tsuchiya N, Kraskov A, Quiroga RQ, Adolphs R, Fried I, Koch C. (2011) A category-specific response to animals in the right human amygdala, Nat Neurosci, 14(10), 1247-9. Pubmed, PMC free text.

Davare, M., Kraskov, A., Rothwell, J. C., and Lemon, R. N. (2011) Interactions between areas of the cortical grasping network, Curr Opin Neurobiol, 21(4), 565-70. Pubmed, PMC free text.

Cerf, M., Thiruvengadam, N., Mormann, F., Kraskov, A., Quian Quiroga, R., Koch, C., & Fried, I., (2010) Online, voluntary control of human temporal lobe neurons, Nature, 467(7319), 1104-1108. PubmedPMC free text

Kraskov, A., Dancause, N., Quallo, M.M., Shepherd, S., and Lemon, R. N. (2009) Corticospinal neurons in macaque ventral premotor cortex with mirror properties: a potential mechanism for action suppression? Neuron 64(6), 922-30. Pubmed, PMC free text

Spinks, R. L.*, Kraskov, A.*, Brochier, T., Umilta, M. A., and Lemon, R. N. (2008) Encoding of grasp by local field potentials and by single neurons recorded simultaneously from M1 and F5 in the awake, behaving macaque monkey, J Neurosci, 28(43), 10961-10971 (*these authors contributed equally). PubmedPMC free text

Pedreira, C., Mormann, F., Kraskov, A., Cerf, M., Fried, I., Koch, C., and Quian Quiroga, R. (2009) Responses of Human Medial Temporal Lobe Neurons Are Modulated by Stimulus Repetition , J Neurophysiol, 103(1), 97-107 PubmedPMC free text

Quian Quiroga, R., Kraskov, A., Koch, C., and Fried, I. (2009) Explicit encoding of multimodal percepts by single neurons in the human brain. Current Biology, 19(15), 1308-13 PubmedPMC free text

Mormann, F., Kornblith, S., Quian Quiaroga, R., Kraskov, A., Cerf, M., Fried, I., and Koch, C. (2008) Latency and selectivity of single neurons indicate hierarchical processing in the human medial temporal lobe, J Neurosci, 28, 8865-8872 Pubmed, PMC free text

Kraskov, A., Quian Quiroga, R., Reddy, L., Fried, I., and Koch, C. (2007) Local Field Potentials and Spikes in the Human Medial Temporal Lobe are Selective to Image Category, J Cogn Neurosci, 19, 479-492 free pdf

Kreuz, T., Mormann, F., Andrzejak, R.G., Kraskov, A., Lehnertz, K., and Grassberger, P. (2007) Measuring synchronization in coupled model systems: A comparison of different approaches. Physica D, 225(1), 29-42

Waydo, S., Kraskov, A., Quian Quiroga, R., Fried, I., and Koch, C. (2006) Sparse representation in the human medial temporal lobe. J Neurosci, 26, 10232-10234 Free full text

Kreiman, G., Hung, C. P., Kraskov, A., Quian Quiroga, R., Poggio, T., and DiCarlo, J. J. (2006) Object selectivity of local field potentials and spikes in the macaque inferior temporal cortex, Neuron, 49, 433-445 doi

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