Dr M. Davare

Human hand function

Lab Head: Dr. Marco Davare

marco_header

m.davare [at] ucl.ac.uk

The hand is the principal organ through which we interact with our environment. Skilled hand function is essential for most aspects of our daily life; it is crucial for our technology, communication and social interactions.

My main interest is to understand how the brain integrates multiple sensory sources to control hand movements.

Research

Previous studies provided a picture of distinct cortical areas distributed within the parieto-frontal network that are necessary to control skilled hand movements. However, the nature and timing of the interactions between these areas, namely AIP, PMv and the primary motor cortex (M1), during visually-guided grasping movements are critical issues that still remained unanswered. Investigating the connectivity between these areas is important because it allows us to shed light on how visual information about the object properties is transferred from one area to another and finally transformed into a precise motor command.

In Prof. Roger Lemon's lab, the exposure to single unit studies of premotor-motor interactions during hand grip in non-human primates led me to pioneer new methods to investigate cortico-cortical connectivity during hand actions. I developed a novel paired-pulse TMS paradigm that opened up the possibility of testing these cortico-cortical interactions in humans.

Click HERE for details about my research projects.

paired_pulse

Publications

2012
17. Davare M, Zénon A, Pourtois G, Desmurget M, Olivier E, Role of the medial part of the intraparietal sulcus in implementing movement direction.
Cereb Cortex. 2012 Jun;22(6):1382-94.

2011
16. Vesia M, Davare M, Decoding action intentions in parieto-frontal circuits. J Neurosci. 2011 Nov 16;31(46):16491-3.

15. Davare M, Kraskov A, Rothwell JC, Lemon RN, Interactions between areas of the cortical grasping network. Curr Opinion in Neurobiology. 2011 Aug;21(4):565-70.

2010
14. Loh MN, Kirsch L, Rothwell JC, Lemon RN, Davare M, Information about the weight of grasped objects from vision and from internal models interacts within the primary motor cortex. J Neurosci. 2010 May 19;30(20):6984-90.
- Faculty of 1000 Biology evaluation: Melvyn Goodale (June 2010) http://www.f1000biology.com/article/id/3404957/evaluation

13. Davare M, Rothwell JC, Lemon RN, Causal connectivity between the human anterior intraparietal area and premotor cortex during grasp. Current Biology. 2010 Jan 26;20(2):176-81.
Comment in Current Biology: 'Brain connectivity: finding a cause' (Lepage JF, Théoret H. 2010 Jan 26;20(2):R66-7)

12. Duque J, Davare M, Delaunay L, Jacob B, Saur F, Hummel L, Hermoye B, Rossion B, Olivier E, Monitoring coordination during bimanual movements; where is the mastermind? Journal of Cognitive Neuroscience. 2010 Mar;22(3):526-42.

Page last modified on 01 oct 12 15:50