UCL Institute of Neurology



Voxel-based morphometry results showing (top) grey matter volume loss and (bottom) white matter volume loss in symptomatic ADAD mutation carriers compared to controls*

Establishing and applying imaging methods and biomarkers to transform the diagnosis, management and treatment of neurological and neurosurgical diseases


Professor Tarek Yousry, Dr med Habil, FRCR

Research Team:

Research Goals

  • Research involving imaging method development and patient-cohort imaging studies covers a wide range of neurological and neurosurgical diseases, including neurovascular disorders, neurooncology, neurodegeneration and Neuroinflammation, as well muscle and peripheral nerves (neuromuscular) disorders. Our aim is to facilitate rapid translation of innovations, including intraoperative imaging, into the clinical environment.

Funded Research Projects

  • Secondary prevention of Alzheimer’s disease. Funded by the EU
  • GLINT: GlucoCEST imaging of neoplastic tumours. Funding from EC-H2020.
  • A gold standard perfusion phantom for quantitative MRI. Funded by SBRI NHS England.
  • High dose Simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage. Funded by the MS Society of GB & NI
  • Feasibility of microstructural and metabolic MRI fingerprinting of human gliomas. Funded by the NIHR BRC
  • Multi-centre optimization and harmonization of MRI image acquisition schemes: a UK-wide coordinated approach to advanced neuroimaging in dementia. Funded by Alzheimer’s Research UK
  • Multi-user ultra-high field clinical imaging research centre for London. Funded by the Wellcome Trust
  • Non-Invasive Imaging of glymphatic clearance: a novel strategy for the early diagnosis of Alzheimer's disease. Funded by EPSRC.
  • Imaging research to facilitate treatments for multiple sclerosis MS Society of GB
  • MRC centre for Neuromuscular disease, MRC
  • MYO-MRI COST Action- BM1304
Recent publications from Neuroradiology

Further information

 * Tentolouris-Piperas et al (2017). Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease. Brain Research Volume 1655, 15 January 2017, Pages 23-32. doi.org/10.1016/j.brainres.2016.11.011