UCL Institute of Neurology


Cognitive Neurology

Five clusters of voxels survive a whole brain correction for multiple comparisons. Peak positive and negative clusters are displayed in axial slices*

Investigating how cognitive processes (thinking, memory and language skills) are damaged by acquired brain injury and how to restore or compensate for their loss.


Professor Alex Leff

Research Team

Research Goals

  • To develop novel, evidence-based therapies for patients with cognitive impairment and to investigate how, at a neural network level, these therapies work.
  • To identify key brain and behaviour markers that will allow us to make individualized predictions of: i) recovery from brain injury; ii) response to therapies for brain injury
  • See also http://www.ucl.ac.uk/aphasialab/

Funded Research Projects

  • Digital neuro-interventions to enhance re-learning in patients with acquired and degenerative brain diseases. Developing three separate digital neuro-interventions for: (1) patients with visuospatial neglect; (2) patients with dementia who forget familiar names; (3) aphasic patients who have word-finding difficulties. Funded by an NIHR (National Institute for Health Research) Research Professorship.
  • The ‘Listen-In’ project: developing, testing and rolling-out at a web-based therapy application for patients with impaired speech comprehension caused by stroke. Funded by the NIHR i4i programme.
  • The Read-Right and Eye-Search projects are for patients with hemianopia that causes, respectively, a reading problem and a problem with visual search. Both therapies work by retraining eye movements, to make them more efficient. Funded by the Stroke Association and NIHR.
  • Back of the brain project: a cross-sectional study with a new approach to cerebral localisation of visual perceptual functions. Funded by the Danish Research Council.
Recent publications from Cognitive Neurology

Further information

 *  Hope et al. Right hemisphere structural adaptation and changing language    skills years after left hemisphere stroke. Brain 2017; 140(6):1718-1728 10.1093/brain/awx086