Professor Sarah Tabrizi, Director of the Huntington’s Disease Centre, UCL Institute of Neurology, gave an inspiring keynote speech at Google’s Zeitgeist. Zeitgeist is a high-profile gathering of business leaders and thinkers. Professor Tabrizi’s speech focused on how research on a genetic dementia like Huntington’s disease may not only offer hope to those who carry the Huntington's gene but also unlock treatments for other more complex dementias such as Alzheimer’s disease.
Publication date: 2 June 2016
A new brain scan being tested at UCL Institute of Neurology to identify Alzheimer’s disease 15 years before symptoms appear was featured on Horizon this month.
Publication date: 19 May 2016
A group exploring dementia and the arts have been invited to take up the 2016-2018 residency in The Hub at Wellcome Collection, a flagship space and resource for interdisciplinary projects exploring health and wellbeing. Bringing together a rich network including scientists, artists, clinicians, public health experts and broadcasters, the group will examine and challenge perceptions of dementia through scientific and creative experimentation. They have been awarded £1 million to develop the project over two years.
Publication date: 24 March 2016
UCL today announced that a team of researchers from UCL and the University of Cambridge led by Professor Sarah Tabrizi, Director of the Huntington’s Disease Centre, UCL Institute of Neurology, have been granted a prestigious Wellcome Trust Collaborative Award in one of the largest investments in Huntington’s Disease (HD) ever given by a public funding body in the UK. The 5-year, £3.4 million investment will support research to help our understanding of disease mechanisms in HD and, importantly, their response to treatment. This valuable work will in turn provide insights into other more common neurodegenerative diseases.
Publication date: 17 February 2016
Institute of Neurology has today announced a free four-week online course
“The Many Faces of Dementia” aiming to provide valuable insights into
through the stories, symptoms and science behind four less common
interactive MOOC (massive open online course) features interviews with
world-leading experts, people with
dementia and their families as well as articles and discussion.
Publication date: 20 January 2016
The UCL Institute of Neurology invited a group of teenage girls from Camden’s Parliament Hill School to visit on 13 October as part of an initiative to encourage more to pursue studies in science, technology, engineering and mathematics (STEM).
Publication date: 23 October 2015
Patients in London are being dosed for the first time with an experimental drug for Huntington’s disease. This breakthrough could be one of the most important developments since the gene for Huntington’s disease was discovered in 1993. The trial of the revolutionary new ‘gene silencing’ treatment is being led by scientists at UCL’s Institute of Neurology. The first patients received doses of the drug at the Leonard Wolfson Experimental Neurology Centre at UCLH's National Hospital for Neurology and Neurosurgery.
Publication date: 19 October 2015
supermarkets Iceland, Asda, Morrisons and Waitrose have
today pledged funds from the new levy on single-use carrier bags to
construction of a new world class dementia research centre at UCL.
Publication date: 5 October 2015
Amyloid beta pathology in the grey matter and blood vessel walls characteristic of Alzheimer’s disease (AD) and the related cerebral amyloid angiopathy (CAA) is observed in the brains of deceased patients who acquired Creutzfeldt–Jakob disease (CJD) following treatment with prion-contaminated human growth hormone.
Publication date: 10 September 2015
A new measure has been developed which can explicitly characterise compensation in Huntington’s disease (HD) gene-carriers prior to clinical diagnosis. Publishing in EBioMedicine, the research team working on the study hope that identifying patterns of compensation in preclinical HD will not only improve understanding of neural mechanisms underlying HD pathology, but also provide potential targets that can be used in the testing of HD therapeutics.
Publication date: 17 August 2015
A novel conceptual framework for tackling the global challenge of dementia has been proposed in an article published in The Lancet.
Publication date: 30 July 2015
A landmark study that has been following a group of people since their birth in the same week in March 1946 is now turning its focus to the risk factors and early signs of dementia.
Publication date: 14 July 2015
Researchers at UCL Institute of Neurology have been awarded a major grant to look at what happens in the brain of people who carry an abnormal gene linked to frontotemporal dementia (FTD) up to 20 years before symptoms start.
Publication date: 13 July 2015
Researchers at the Medical Research Council’s Prion Unit at the UCL Institute of Neurology have identified a naturally occurring variant of the human prion protein that produces resistance to prion diseases such as Creutzfeldt-Jakob disease (CJD). The findings, published in Nature, could give important insight into other human brain diseases that lead to dementia.
Publication date: 11 June 2015
Behavioural changes such as irritability, sleep changes and depression are common characteristics in the early stages of familial Alzheimer's disease, according to research published in Brain.
Publication date: 27 April 2015
Research using brain imaging has found changes in the brain can be identified in people with frontotemporal dementia (FTD) 5-10 years before symptoms appear.
Publication date: 16 April 2015
A new test has been able to
measure for the first time the build-up of a harmful mutant protein in the
nervous system of patients during the progression of Huntington’s disease (HD).
Publication date: 14 April 2015
Early onset Alzheimer's occurs in people under 65 and represents fewer than 5% of people with the condition. In a few hundred families worldwide scientists have pinpointed a few rare gene mutations which trigger the disease across many generations.
Publication date: 13 March 2015
One of the major themes of the new exhibition, History Is Now: 7 Artists Take On Britain, is the BSE crisis.
Publication date: 24 February 2015
As part of the Clinical Research Infrastructure Initiative, UCL has been awarded £13.5 million for a number of projects to help advance clinical research.
Publication date: 23 October 2014
Scientists at UCL Institute of Neurology and the Max Planck Institute for Biology of Ageing in Cologne have discovered how a specific genetic mutation may damage nerve cells in frontotemporal dementia and motor neurone disease.
Publication date: 11 August 2014
Professor Sarah Tabrizi (Department of Neurodegenerative Diseases, UCL Institute of Neurology and
Honorary Consultant Neurologist at the National Hospital of Neurology and
Neurosurgery) and Professor Cathy Price (Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology) have been recognised for their contribution to the advancement of medical science by election to the Fellowship of the Academy of Medical Sciences.
Publication date: 12 May 2014
There are real concerns
over the number of people in the UK that, although well, maybe infected with Variant Creutzfeldt-Jakob Disease (vCJD),
the human form of mad cow disease.
Publication date: 7 March 2014
Dame Sally Davies, the Chief Medical Officer, has appointed Professor Martin Rossor (UCL Institute of Neurology) as the new NIHR National Director for Dementia Research.
Publication date: 4 March 2014
Lowering levels of toxic protein reverses abnormalities in cells from patients with Huntington's disease
UCL scientists, led by Professor Sarah Tabrizi at the UCL Institute of Neurology, in collaboration with colleagues at the University of Massachusetts Medical School, have shown for the first time that switching off the mutant protein that causes the fatal brain disorder Huntington’s disease can reverse abnormalities in living cells taken from patients with the disease.
Publication date: 24 January 2014