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UCL Institute of Neurology Professor John Hardy is first UK winner of $3m Breakthrough Prize in Life Sciences
Publication date: 9 November 2015
John Hardy (Department of Molecular Neuroscience, UCL Institute of Neurology) was last night awarded
the $3 million Breakthrough Prize in Life Sciences for his pioneering
into the genetic causes of Alzheimer’s disease, other forms of dementia
The Breakthrough Prize in Life Sciences honours ‘transformative advances toward understanding living systems and extending human life’. This is the first time that the prize has been awarded to a UK researcher, reflecting UCL’s world-leading position in dementia research.
MRC Centre-BRC MRI Biomarker Collaboration in Lancet Neurology: Important implications for experimental trials in Neuromuscular Diseases
Publication date: 9 November 2015
A UCL Institute of Neurology study published in Lancet Neurology this week provides important prospective evidence that quantitative MRI can reliably and sensitively track disease progression in Neuromuscular Diseases. The research shows that the MRI biomarkers developed by the MRC Centre team have real potential to become the widely adopted surrogate endpoint in neuromuscular trials.
Movement Making and Action Potential: collaborations raising awareness of Motor Neuron Disease
Publication date: 6 November 2015
Two Motor Neuron Disease (MND) awareness events, co-organised by Dr Rickie Patani, UCL Institute of Neurology, Dr Emma Hodson-Tole, Manchester Metropolitan University (MMU), and Motor Neuron Disease Association (MNDA) were showcased during the recent Manchester Science Festival. Both activities were developed to try and translate to a wide audience the cycle scientific investigation goes through, raising awareness of MND, the MND Association and the research supported by the charity, as well as inspiring the next generation of scientists.
Piepenbrock Group and German Center for Neurodegenerative Diseases honour Professor Hardy
Publication date: 17 August 2015
Professor John Hardy, UCL Institute of Neurology, will be awarded this year’s “Hartwig Piepenbrock-DZNE Prize” honouring his seminal contributions to the study of Alzheimer’s disease.
The award ceremony will take place on World Alzheimer's Day, September 21, 2015, in Bonn, Germany.
Professor Hardy has made ground-breaking findings on the molecular causes of this brain disorder. His discoveries provide the basis for therapeutic approaches and potential medicines.
BRC funding for experimental medicine research projects
Publication date: 30 July 2015
UCL Hospitals Biomedical Research Centre have funded several research projects in the Neurosciences programme, including four from UCL Institute of Neurology:
Research into genetic influences on epilepsy and migraines
Publication date: 30 June 2015
Researchers at UCL Institute of Neurology have begun to investigate genetic influences on neurological disorders such as ataxia, epilepsy and rare and severe headache disorders.
Professor Lees awarded ABN Medal 2015
Publication date: 1 June 2015
We are pleased to announce that Professor Andrew Lees, Professor of Neurology, National Hospital for Neurology and Neurosurgery, and Emeritus Director, Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, is the ABN Medallist 2015.
ABN Medal is awarded annually to recognise outstanding contributions by British
and Irish neurologists to the science or practice of neurology, or for
contributions to the Association. Professor Lees’ medallist lecture
was entitled Butterflies of the Soul.
Professor Hardy elected member of EMBO
Publication date: 21 May 2015
Professor John Hardy, UCL Institute of Neurology, has been elected to EMBO membership, alongside other outstanding researchers in the life sciences.
Working with Saracens to monitor concussion in rugby
Publication date: 21 May 2015
A new genetic switch uncovered in the long genes expressed in our brain
Publication date: 14 May 2015
A new mechanism for splicing-based gene
regulation has been discovered in vertebrates by a team of researchers at UCL Institute of
Neurology and UCL Genetics Institute, showing that sometimes
cells select a piece of a gene as an exon, but then later discard this piece in
the process called ‘recursive splicing’.
Professor Mary Reilly is elected to be the first female President of the Association of British Neurologists in 83 years
Publication date: 24 March 2015
Professor Mary Reilly has been elected ABN President from 2017-2019 and is President elect from 2015-2017.
Professor Reilly has been a consultant Neurologist at Queen Square since 1998 and was promoted to Professor of Clinical Neurology at UCL in 2010. She is head of the Division of Clinical Neurology and Co-Director of the MRC Centre for Neuromuscular Diseases in the Department of Molecular Neurosciences at UCL Institute of Neurology. She is internationally recognised for her expertise in research and clinical practice related to peripheral nerve diseases.
Structure of genetic messenger molecules reveals key role in diseases
Publication date: 19 March 2015
Messenger RNAs (mRNA) are linear molecules that contain instructions for producing the proteins that keep living cells functioning. A new study by UCL researchers has shown how the three-dimensional structures of mRNAs determine their stability and efficiency inside cells. This new knowledge could help to explain how seemingly minor mutations that alter mRNA structure might cause things to go wrong in neurodegenerative diseases like Alzheimer’s.
BRC awards £700,000 to neuroscience projects
Publication date: 21 January 2015
The BRC have awarded over £700,000 to three exciting clinical research projects in neuroscience.
The awards were confirmed last month for the following innovative projects:
Professor Lees receives Jay Van Andel Award for Outstanding Research in Parkinson’s Disease
Publication date: 12 September 2014
Creating brain cells from skin to study Alzheimer's
Publication date: 8 September 2014
GCH1 gene and Parkinson’s risk
Publication date: 5 August 2014
A study published in Brain, led by researchers at UCL Institute of Neurology, has shown that genetic mutations which cause a decrease in dopamine
production in the brain and lead to a form of childhood-onset Dystonia,
also play a role in the development of Parkinson’s disease.
Double mutation linked to frontotemporal dementia
Publication date: 5 August 2014
Immune system implicated in dementia development
Publication date: 18 June 2014
Vitamin B3 treatment for ataxia shows promise in first human trial
Publication date: 1 May 2014
Professor Hardy awarded Thudichum Medal by Biochemical Society
Publication date: 14 March 2014
Professor Hardy awarded Dan David Prize for work on the amyloid gene encoding APP
Publication date: 24 February 2014
Professor John Hardy, Head of Molecular Neuroscience at UCL Institute of Neurology, has been
awarded the Dan David Prize for his work on the amyloid gene encoding the amyloid precursor protein (APP).
This is a prestigious international prize which annually awards three prizes of US$ 1 million each for achievements having an outstanding scientific, technological, cultural or social impact on our world. Each year fields are chosen within the three Time Dimensions - Past, Present and Future.
NIHR award £650,000 for research into rare neurodegenerative and neuromuscular diseases
Publication date: 21 February 2014
The National Institute of Health Research (NIHR) Rare Diseases Translational Research Collaboration has awarded a total of £650,000 to extend research into rare neurodegenerative and neuromuscular diseases.
Predicting age at onset in SCA1 : does size matter?
Publication date: 18 December 2013
Research at the UCL Institute of Neurology, led by Paola Giunti, and the MRC National Institute for Medical Research, and published in the journal PloS Genetics, has shown how the length and the nature of gene repeat expansions affects spinocerebellar ataxia type 1 (SCA1).
Riboflavin Treatment for Childhood onset Motor Neuron Disease
Publication date: 5 December 2013
A clinical and genetic study based at UCL Institute of Neurology and the Institute of Child Health, recently published in Brain, has used next generation sequencing to identify riboflavin transporter gene defects as the defective pathway in a severe form of childhood motor neuron disease. Children with these defects significantly respond to high dose riboflavin.
Different gene expression in male and female brains helps explain differences in brain disorders
Publication date: 22 November 2013
UCL scientists have shown that there are widespread differences in how genes, the basic building blocks of the human body, are expressed in men and women’s brains.