UCL Institute of Neurology



Changes to gut bacteria could hold key to slowing down Motor Neurone Disease

A team from the Leonard Wolfson Experimental Neurology Centre (LWENC), run jointly by the National Hospital for Neurology and Neurosurgery (NHNN) and UCLInstitute of Neurology, have been awarded the first ever major UK grant to investigate how changes in gut bacteria could slow the progression of neurodegenerative disorders such as Motor Neuron Disease (MND).

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Evidence of brain damage found in former footballers

Evidence of chronic traumatic encephalopathy (CTE), a potential cause of dementia caused by repeated blows to the head, has been found in the brains of former association football (soccer) players examined at the Queen Square Brain Bank, UCL Institute of Neurology.

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Science begins in the new Francis Crick Institute building

The first scientists have moved into the new £650 million Francis Crick Institute building in London and are starting work in their purpose-built labs. Next to St Pancras station and the British Library, the Crick will be the biggest biomedical research institute under one roof in Europe.

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Banking Britain's brains: the story of a scientific resource

Dr Tammaryn Lashley, Alzheimer's Research UK Senior Research Fellow, UCL Institute of Neurology, was interviewed on the Victoria Derbyshire show this week, discussing the work of brain banks such as the Queen Square Brain Bank.

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BBC film highlights dementia research

A new BBC One film examining the science behind dementia, which was partly filmed at the Queen Square Brain Bank and the Leonard Wolfson Experimental Neurology Centre (LWENC), UCL Institute of Neurology, aired last week.

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Jernej Ule elected member of EMBO

We are delighted to announce that Jernej Ule, UCL Institute of Neurology, has been elected to EMBO membership, alongside 57 other outstanding researchers in the life sciences.

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Parkinson's chromosome deletion linked to other genetic disorders

Researchers, led by BRC-supported Professor Nicholas Wood, UCL Institute of Neurology, have made a breakthrough in their understanding of Parkinson’s disease after they discovered a chromosome deletion linked to Parkinson’s disease and other genetic disorders.This study analysed multiple datasets, including significant contribution from UKPD study and the IPDGC consortium, both had received funding from The Wellcome Trust/MRC. This study found people with Parkinson’s disease had a piece of DNA missing from chromosome 22q. This particular ‘chromosome deletion’ has up until now normally been associated with DiGeorge syndrome, a genetic disorder usually noticeable at birth that can cause heart defects, problems with the mouth, feeding and hearing, and multiple other diseases.

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Study shows abnormal protein aggregation causes inherited neuropathy: potential new target for therapy

A collaboration between the Medical Research Council (MRC) Centre for Neuromuscular Diseases at UCL Institute of Neurology, the Medical University Vienna and the John P. Hussman Institute for Human Genetics, University of Miami has identified abnormal protein aggregation secondary to mutations in the Neurofilament heavy chain as a cause of autosomal Dominant Charcot Marie Tooth disease type 2 (CMT2).

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New drug shows promise against muscle wasting disease

A new drug to treat the muscle wasting disease inclusion body myositis (IBM) reverses key symptoms in mice and is safe and well-tolerated in patients, finds a new study led by the Medical Research Council (MRC) Centre for Neuromuscular Diseases at University College London (UCL) Institute of Neurology and the University of Kansas Medical Center.

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Alzheimer’s researcher wins top European research award

Dr Rita Guerreiro, an Alzheimer's Society senior research fellow who works at the Department of Molecular Neuroscience at the UCL Institute of Neurology,  has been awarded the prestigious Fondazione Gino Galletti Neuroscience Prize 2015.

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MRC Centre-BRC MRI Biomarker Collaboration in Lancet Neurology: Important implications for experimental trials in Neuromuscular Diseases

A UCL Institute of Neurology study published in Lancet Neurology this week provides important prospective evidence that quantitative MRI can reliably and sensitively track disease progression in Neuromuscular Diseases. The research shows that the MRI biomarkers developed by the MRC Centre team have real potential to become the widely adopted surrogate endpoint in neuromuscular trials.

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Movement Making and Action Potential:  collaborations raising awareness of Motor Neuron Disease

Two Motor Neuron Disease (MND) awareness events, co-organised by Dr Rickie Patani, UCL Institute of Neurology, Dr Emma Hodson-Tole, Manchester Metropolitan University (MMU), and Motor Neuron Disease Association (MNDA) were showcased during the recent Manchester Science Festival. Both activities were developed to try and translate to a wide audience the cycle scientific investigation goes through, raising awareness of MND, the MND Association and the research supported by the charity, as well as inspiring the next generation of scientists.

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