- Clinical trials are vital tools in stroke research
- New gene identified for Dominant Congenital Spinal Muscular Atrophy and Hereditary Spastic Paraparesis
- Teaching Awards 2013
- 14th Annual Queen Square Symposium
- TRACK-HD study identifies early predictors of disease progression in Huntington’s disease
- The Great Brain Experiment: crowdsourcing data on how we think and act
- Psychogenic diseases linked to abnormal brain activity
- Human Brain Project wins major EU funding
- Gene mutation causes familial form of cranio-cervical dystonia
- Professor Ray Dolan awarded prestigious Klaus Joachim Zülch Prize
- Professor Dimitri Kullmann elected Editor of Brain
- Hereditary Whispering Dystonia gene identified
- Belgian Stroke Council Award to UCL student
- Professor Nicholas Wood appointed as neuroscience programme director for UCLH NIHR Biomedical Research Centre (BRC)
- UCL neuroscientists awarded highly competitive ERC Advanced Grants
- Drugs could provide new treatment for epilepsy
- Breakthrough in the treatment of drug-resistant epilepsy
- UCL Institute of Neurology enters gene-editing research collaboration with Horizon Discovery
- Lifetime achievement award for Professor Thompson’s MS work
- New biography of Gowers released
- Repurposed cardiac sodium channel blocker brings significant benefit for patients with a rare neuromuscular disease
- Toxic protein build-up in blood shines light on fatal brain disease
- Professor Lees receives prestigious German Society of Neurology award
- Cause of Alternating Hemiplegia identified
- Results from stroke treatment study are in top 10 of Lancet’s most highly cited papers
- Skin patch improves attention span in stroke patients
- Genetic study identifies treatable pathway in childhood motor neuron disease
- Awards and congratulations
- Medical Photographer Wins Wellcome Image Awards
- Prestigious Junior Investigator Award for stroke research
- Unlocking the mysteries of the mind
- Professor Simon Shorvon appointed Harveian librarian at the Royal College of Physicians
- Parliamentary Group Visit the Institute
- Cultural Consultation Service website launches
- Clinical Teaching Awards 2011/12
- Prestigious European Science Foundation networking grant awarded to Institute of Neurology professor
- International project to determine vascular contribution to neurodegeneration begins
- Prime Minister visits UCL Institute of Neurology
- Institute scientist takes his research to Parliament
- Professor Ray Dolan gives the prestigious Alan Turing Lecture
- The Performing Brain – A moving story? Friday 16th March
- Are we hard wired to be rebellious?
- Detecting stroke
- Queen Square Clinical Trial Centre launched
- New funding to preserve unique archives
- Major new funding for research into epilepsy is announced
- Professor Ray Dolan elected Fellow of the APS
- New Years Honours
- Brain Implant Cures Woman's Tourette's Tics
- IoN News Archive (2010)
- IoN News Archive (2009)
- IoN launches new website
- Professor Hardy receives IFRAD 2011 European Grand Prize for Alzheimer's Research
- Medical Illustrators presented prestigious Wellcome Image Award
- Neurodegenerative disease research projects secure international collaborative funding
- Novel treatments for epilepsy
- Stem cell study offers hope for Parkinson’s patients
- Professor Alan Thompson appointed as Dean of UCL Faculty of Brain Sciences
- Wellcome Trust Centre for Neuroimaging student receives Young Researcher Award
- UCL Alzheimer’s researcher receives lifetime achievement award
- Dr Jonathan Schott receives the US Alzheimer Association 2011 de Leon Prize in Neuroimaging: New Investigator Award
- Study reveals genetic clues underlying progressive supranuclear palsy
- UCL neuroscientists among the most cited in Parkinson’s disease research
- Professor Maguire awarded Kemali prize
- Award for Professor Roger Lemon
- Professor Dimitri Kullmann recognised for his outstanding research
- 'Consciousness connections' revealed in coma brains
- Four UCL neuroscientists elected to the Academy of Medical Sciences
- May 25 Marks World MS Day
- Prion infection begins after one minute of exposure
- Successes of Deep Brain Stimulation for patients with Parkinson's disease
- Professor Hanna invited to give prestigious ANZAN Lecture
- Severe reaction to epilepsy drug linked to genetic variant
- Rhythm and the perception of time
- How prions propagate
- Understanding how the brain determines coincidence
- Lancet papers testament to clinical impact and significance of neuroscience research at UCL
- World’s first blood test for vCJD
- Researchers identify 5 new genetic variations in total of 11 thought to be important in Parkinson’s Disease risk
- IoN scientist receives prize to promote German-Anglo relations
- Epilepsy surgery shows promising results, says study
- Scientists make step towards better understanding of the brain's teaching signals
- UCL scientists get £88k boost to study hearing problems in Alzheimer’s
- Professor Jon Driver
- Wellcome Trust Centre for Neuroimaging researcher scoop Lloyd’s 2011 Science of Risk Prizes
- Launch of the UCL Institute of Neurology YouTube channel
- Researchers move closer to finding successful drugs to treat Huntington’s disease
- Imaging the evolution of multiple sclerosis
- Brain changes seen in cabbies who take 'The Knowledge'
- Professor Brown gives Annual Stroke Association Royal Lecture
- New Institute Director
- Wolfson Foundation awards £20million to UCL for experimental neurology centre
- Thinking of studying at UCL next year?
Published: Jul 8, 2013 2:00:00 PM
Published: Jul 5, 2013 5:29:00 PM
Published: Jun 1, 2013 3:31:00 PM
Published: May 15, 2013 4:45:54 PM
Stem cell study offers hope for Parkinson’s patients
24 August 2011
Stem cell study offers hope for Parkinson’s patients
24 August 2011
Scientists have for the first time generated stem cells from one of the most rapidly progressing forms of Parkinson’s disease.
The development will help research into the condition as it will enable scientists to model the disease in the laboratory to shed light on why certain nerve cells die.
Scientists, funded with a £300,000 grant from the charity Parkinson’s UK, took skin samples from a patient diagnosed with one of the most progressive types of Parkinson’s.
The research, led by the University of Edinburgh in collaboration with University College London researchers, then used these skin cells to generate brain nerve cells affected by the disease.
The ability to generate these nerve cells will make it easier to monitor the effectiveness of potential new drugs that could slow or halt progress of the condition.
The aim would be to find drugs that can prevent the death of these key cells – known as neurons – which break down as a result of Parkinson’s.
Dr Tilo Kunath, of the University of Edinburgh’s Medical Research Council Centre for Regenerative Medicine, said: “Current drugs for Parkinson’s alleviate symptoms of the condition. Modelling the disease in a dish with real Parkinson’s neurons enables us to test drugs that may halt or reverse the condition.
“This study provides an ideal platform to gain fresh insight into the condition, and opens a new area of research to discover disease-modifying drugs.”
The neuron cells were generated from a patient with a form of Parkinson’s that progresses rapidly and can be diagnosed in people in their early 30s.
People with this form of Parkinson’s have twice as many of the genes that produce a protein – alpha synuclein – compared with the general population.
Although this form of Parkinson’s is rare the protein involved is linked to virtually all types of the disease.
Dr Michael Devine, of UCL’s Institute of Neurology said, “Understanding such a progressive form of the disease will give us insight into different types of Parkinson’s. As this type of Parkinson’s progresses rapidly it will also make it easier to pick up the effects of drugs tested to prevent nerve cells targeted by the disease from dying.”
The research was published in the journal Nature Communications.
Dr Kieran Breen, Director of Research and Development at Parkinson’s UK, said: “Although the genetic mutation that leads to this progressive form of Parkinson’s is rare this exciting study has the potential to bring about a huge breakthrough in Parkinson’s research.
“This is just the kind of innovative research that Parkinson’s UK is committed to funding as we move closer to a cure.”
Image: Dopamine-producing nerve cells grown from stem cells of a Parkinson's patient. Credit: The University of Edinburgh