- Queen Square authors prominent in Brain collection of classic articles
- Toxic proteins implicated in frontotemporal dementia and motor neurone disease
- Double mutation linked to frontotemporal dementia
- Equation to predict happiness
- Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia
- Researchers test whether diabetes drug can help Parkinson’s patients
- Acute optic neuritis: a review and proposed protocol
- Hippocampal subfield size predicts the precision of memory recall
- Immune system implicated in dementia development
- UCL and Chiesi Group announce partnership to develop a novel therapeutic for birth asphyxia
- Professor Golay made a Fellow of the ISMRM
- The new Leonard Wolfson Experimental Neurology Centre (LWENC) has opened for clinical studies and trials
- Professor Rees wins UCLU Student Choice Teaching Award
- New epilepsy treatment offers ‘on demand’ seizure suppression
- Professor Tabrizi and Professor Price elected to Fellowship of the Academy of Medical Sciences.
- Professor Dolan and Professor Friston elected to EMBO membership
- Vitamin B3 treatment for ataxia shows promise in first human trial
- Teaching Awards 2014
- Light-activated neurons from stem cells restore function to paralysed muscles
- UCL and Max Planck Society invest €5m to open world’s first computational psychiatry centre
- Successful launch of new annual leading edge neurology course
- Statins could help control MS
- Professor Hardy awarded Thudichum Medal by Biochemical Society
- Population Screening for vCJD Using a Novel Blood Test
- Chief Medical Officer appoints Professor Rossor as NIHR National Director for Dementia Research
- New partnership between UCLP brain tumour scientists and Brain Tumour Research
- Professor Hardy awarded Dan David Prize for work on the amyloid gene encoding APP
- NIHR award £650,000 for research into rare neurodegenerative and neuromuscular diseases
- Lowering levels of toxic protein reverses abnormalities in cells from patients with Huntington's disease
- Major initiative in understanding synaptic basis of neuropsychiatric disease
- Visit to the Berlin School of Mind and Brain
- Institute of Neurology ranked as the world’s top institution for epilepsy research.
- Predicting age at onset in SCA1 : does size matter?
- UCL takes the lead with £8.5m funding for dementia research
- Secretary of State visits leading dementia research projects
- Riboflavin Treatment for Childhood onset Motor Neuron Disease
- Dreading pain can be worse than pain itself
- Different gene expression in male and female brains helps explain differences in brain disorders
- New £20m centre pioneers first-in-man trials for neurodegenerative diseases
- RNA build-up linked to dementia and motor neuron disease
- Researchers estimate one in 2,000 people in the UK carry variant CJD proteins
- Professor Alan Thompson discusses Atlas of MS on Lancet News
- Wellcome Trust Principal Fellowship award to explore neural coding with the tripartite synapse
- Marsden's Book of Movement Disorders wins Neurology first prize at the 2013 BMA Book Awards
- Scientists develop refined diagnostic tool for inherited dementias
- Genetic mutations linked to Parkinson's Disease
- P-glycoprotein over-activity and drug resistance in temporal lobe epilepsy
- New Yale-UCL collaboration in brain aneurysm genetics
- ‘Risky’ stroke prevention procedure may be safe in some patients
- The Michael J. Fox Foundation awards grant for Exenatide research
- Institute Professor leads cross-disciplinary study on use of glucose in detecting cancer.
- Irreversible tissue loss seen within 40 days of spinal cord injury
- From Bedside to Bench in the Institute’s MRC Centre for Neuromuscular Diseases
- Centralising acute stroke services has saved more than 400 lives since 2010
- Rapid Response Innovation Award from The Michael J. Fox Foundation
- Predicting Language Outcome and Recovery After Stroke (PLORAS) project launches new website
- BRC awards over £500k to neuroscience projects
- ABTA Winners
- Diabetes drug could help treat Parkinson's Disease
- Clinical trials are vital tools in stroke research
- New gene identified for Dominant Congenital Spinal Muscular Atrophy and Hereditary Spastic Paraparesis
- Teaching Awards 2013
- 14th Annual Queen Square Symposium
- TRACK-HD study identifies early predictors of disease progression in Huntington’s disease
- The Great Brain Experiment: crowdsourcing data on how we think and act
- Psychogenic diseases linked to abnormal brain activity
- Human Brain Project wins major EU funding
- Gene mutation causes familial form of cranio-cervical dystonia
- Professor Ray Dolan awarded prestigious Klaus Joachim Zülch Prize
- Professor Dimitri Kullmann elected Editor of Brain
- IoN News Archive (2012)
- IoN News Archive (2011)
- IoN News Archive (2010)
- IoN News Archive (2009)
- GCH1 gene and Parkinson’s risk
Published: Jan 16, 2014 12:32:49 PM
Published: May 11, 2013 3:39:00 PM
Published: Aug 12, 2014 1:23:13 PM
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Published: Jul 30, 2014 4:41:41 PM
IoN News Archive (2010)
24 December 2010: New hope for cluster headache sufferers
The pain of cluster headaches (CH) is notoriously excruciating and usually described as one of the most distressing conditions known to mankind. Female patients describe attacks as worse than childbirth and patients are occasionally driven to suicide. Attacks last between 15 minutes and three hours and can occur up to eight times a day.
For a small group of CH patients there has been no solution. Until now.
The treatment, known as deep brain stimulation, is already used to treat other neurological conditions such as Parkinson’s disease and dystonia. In CH patients, it is used to target a part of the brain (the posterior hypothalamus) which is overactive during the headaches. An electrode is inserted into the brain and linked to a stimulator under the chest. When the stimulator is switched on, an electric current passes into the brain, blocking the damaging signals that cause cluster headaches.
This new method of treating cluster headaches follows on from pioneering research at Queen Square, where the NHNN and the nearby Institute of Neurology at UCL are housed.
The research, which goes back a decade, pinpointed a particular region of the brain (the posterior hypothalamus) and studies revealed the presence of increased blood flow in this region during a cluster headache attack, a sure sign of increased activity.
Early pilot results of DBS in a small number of patients with unremitting chronic cluster headaches were very encouraging and this led two consultants, neurologist Manjit Matharu and neurosurgeon Ludvic Zrinzo to introduce the procedure at the NHNN.
Mr Matharu and Mr Zrinzo said: “We are really excited about the early indications from using DBS in this way. Patients who suffer from this excruciating condition come to us at their wits’ end and for many of them we are a last resort. Unless you have experienced cluster headaches you cannot underestimate the impact they have on the lives of sufferers and their families. If we can help them in any way it’s immensely rewarding,” they said.
read more >> UCLH News | BBC News including film footage
24 December 2010: IoN Student wins Santander Formula One Scholarship
Martin, who is Argentinian, says he was surprised and delighted to receive this prestigious scholarship, established to mark the bicentennial celebrations of Argentina, Chile, Colombia and Mexico.
The scholarships are awarded to the academically best candidate accepted for study at UCL from each of the ten Santander network countries.
The MSc Clinical Neurology programme is an intense one year academic course based in Queen Square for clinicians from around the world.
read more >> Santander Master's Scholarships | MSc in Clinical Neurology
22 December 2010: Alzheimer’s changes detectable in healthy elderly
The approach could allow scientists to test treatments or preventions far earlier in the disease, when experts believe they could be more effective.
The findings of the study are published online this week in Annals of Neurology.
The researchers studied 105 cognitively normal individuals from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). They split this group into those with high and low levels of cerebrospinal fluid (CSF) amyloid, a protein which is typically reduced in the CSF of patients with Alzheimer’s disease.
MRI scan measurements over 12 months were used to calculate the brain shrinkage rate. The team also checked other characteristics such as the presence of known Alzheimer’s risk gene APOE4.
The results revealed that the brains of those normal individuals with low CSF levels of amyloid (38% of the group), shrank twice as quickly as the other group. They were also five times more likely to possess the APOE4 risk gene and had higher levels of another culprit Alzheimer’s protein, tau.
Study lead author Dr Jonathan Schott from the Dementia Research Centre (UCL Institute of Neurology) said: “In this study of healthy people in their 70s and 80s we found that about one in three had a spinal fluid profile consistent with Alzheimer’s disease. Using MRI scanning, we showed that these individuals also had increased brain shrinkage over the following year.
“The significance of these findings will only be clear with longer clinical follow-up, but may suggest that these individuals are at increased risk of developing dementia. If so these results add to a growing body of work suggesting that Alzheimer’s disease starts many years before the onset of symptoms.”
Rebecca Wood, Chief Executive of the Alzheimer’s Research Trust, the leading UK dementia research charity, said: “We are hamstrung by our inability to accurately detect Alzheimer’s, but these findings could prove to be pivotal. Spotting Alzheimer’s early is essential to the global research effort to beat the disease. We know that treatments for many diseases can be more successful if given early and this is likely to be true for Alzheimer’s. It will be crucial to keep following the study group to see how many develop Alzheimer’s, and to expand the research to test the approach further.
“Findings like these underline the importance of research, but detecting Alzheimer’s is only the first step. If we are to defeat the disease, we must invest in research into preventions and treatments now before our dementia crisis spirals out of control.” More...
15 December 2010: Fighter pilots' brains are ‘more sensitive
The study, published today in the Journal of Neuroscience, compares the cognitive performance of 11 front-line RAF (Royal Air Force) Tornado fighter pilots to a control group of a similar IQ with no previous experience of piloting aircraft. All the participants completed two ‘cognitive control’ tasks which were used to investigate rapid decision making. Diffusion tensor imaging (DTI), a type of MRI brain scan, was then used to examine the structure of white matter connections between brain regions associated with cognitive control.
The researchers found that fighter pilots have superior cognitive control, showing significantly greater accuracy on one of the cognitive tasks, despite being more sensitive to irrelevant, distracting information. The MRI scans revealed differences between pilots and controls in the microstructure of white matter in the right hemisphere of the brain.
Senior author Professor Masud Husain, UCL Institute of Neurology (Department of Brain Repair and Rehabilitation) and UCL Institute of Cognitive Neuroscience, said: “We were interested in the pilots because they’re often operating at the limits of human cognitive capability – they are an expert group making precision choices at high speed.
“Our findings show that optimal cognitive control may surprisingly be mediated by enhanced responses to both relevant and irrelevant stimuli, and that such control is accompanied by structural alterations in the brain. This has implications beyond simple distinctions between fighter pilots and the rest of us because it suggests expertise in certain aspects of cognition are associated with changes in the connections between brain areas. So, it’s not just that the relevant areas of the brain are larger – but that the connections between key areas are different. Whether people are born with these differences or develop them is currently not known.”
The study tasks were designed to assess the influence of distracting information and the ability to update a response plan in the presence of conflicting visual information. In the first task, participants had to press a right or left arrow key in response to the direction of an arrow on a screen in front of them, which was flanked by other distracting arrows pointing in different directions. In the second task, they had to respond as quickly as possible to a ‘go’ signal, unless they were instructed to change their plan before they had even made a response.
The results of the first task showed that the expert pilots were more accurate than age-matched volunteers, with no significant difference in reaction time – so, the pilots were able to perform the task at the same speed but with significantly higher accuracy. In the second task, there was no significant difference between the pilots and volunteers, which the authors say suggests that expertise in cognitive control may be highly specialised, highly particular to specific tasks and not simply associated with overall enhanced performance.
These findings suggest that in humans some types of expert cognitive control may be mediated by enhanced response gain to both relevant and irrelevant stimuli, and is accompanied by structural alterations in the white matter of the brain.
The research was supported by funding from the Wellcome Trust, the Medical Research Council and the NIHR Specialist Biomedical Centre at UCL/UCLH NHS Trust
10 December 2010: World-leading scientist secures funding for gene research
Professor John Hardy FRS and his team at the UCL Institute of Neurology (Department of Molecular Neuroscience) , are beginning an ambitious new study that will see them attempt to identify genes that increase the risk of developing Alzheimer’s.
Funded by a £346,000 grant from the Alzheimer’s Research Trust, Prof Hardy plans to sequence every gene in 500 people with Alzheimer’s, and will compare them with the genes of healthy people.
Their work will reveal the genetic changes responsible for Alzheimer’s, giving doctors a better chance of predicting who is at risk of developing the disease.
Prof Hardy said: “Britain has played a leading role in research into the genetics of Alzheimer’s disease, and already we are beginning to make real progress. This study should give us a much greater understanding of the causes of Alzheimer’s, and should also tell us more about how we can intervene and stop the disease progressing.”
read more >> Alzheimer's Research Trust press release
3 December 2010: New brain imaging tests to track Huntington’s
29 November 2010: 2010-11 IoN PhD Studentship Round Now Open
14 October 2010: Parkinson's UK Fellowship Award
20 September 2010: Scientists identify link between introspection and brain structure
13 September 2010: Stents may double the risk of stroke in patients over 70
10 September 2010: Epilepsy prizes
10 September 2010: Developing a cell library resource for dementia research
27 August 2010: Lizard venom offers hope for Parkinson’s disease patients
27 August 2010: Research shows that two heads are better than one
9 August 2010: Win for IoN at Shape of Science Symposium
29 July 2010: Wellcome Success
18 June 2010: Brain study reveals that agreement is rewarding
17 June 2010: Queen's Birthday Honours
14 June 2010: New website to help stroke survivors learn to read again
28 April 2010: St Peter's Medal for Professor Clare Fowler
23 April 2010: Researchers to study how the brain 'rewires itself'
23 April 2010: Robot trainer to benefit stroke patients
20 April 2010: IoN brings the scientific method to London primary schools
13 April 2010: Queen Square Symposium success
11 April 2010: Professor John Duncan appointed as NIHR Senior Investigator
31 March 2010: Award for Professor Chris Frith
26 March 2010: Professor Lees awarded first Lord Brain Memorial Lecture
14 March 2010: Traces of the past: computer algorithm ‘reads’ memories
4 March 2010: Michael J. Fox Foundation awards IoN researcher grant to advance Parkinson's research.
13 January 2010: A role for astrocytes in learning and memory?
7 January 2010: Prestigious stroke program grant awarded
5 January 2010: New centre brings hope to patients with muscle wasting diseases
22 March 2010: Prestigious European research grant awarded