2012 IoN News Archive
- Hereditary Whispering Dystonia gene identified
- Belgian Stroke Council Award to UCL student
- Professor Nicholas Wood appointed as neuroscience programme director for UCLH NIHR Biomedical Research Centre (BRC)
- UCL neuroscientists awarded highly competitive ERC Advanced Grants
- Drugs could provide new treatment for epilepsy
- Breakthrough in the treatment of drug-resistant epilepsy
- UCL Institute of Neurology enters gene-editing research collaboration with Horizon Discovery
- Lifetime achievement award for Professor Thompson’s MS work
- New biography of Gowers released
- Repurposed cardiac sodium channel blocker brings significant benefit for patients with a rare neuromuscular disease
- Toxic protein build-up in blood shines light on fatal brain disease
- Professor Lees receives prestigious German Society of Neurology award
- Cause of Alternating Hemiplegia identified
- Dr John Morgan-Hughes
- Results from stroke treatment study are in top 10 of Lancet’s most highly cited papers
- Skin patch improves attention span in stroke patients
- Genetic study identifies treatable pathway in childhood motor neuron disease
- Awards and congratulations
- Medical Photographer Wins Wellcome Image Awards
- Prestigious Junior Investigator Award for stroke research
- Unlocking the mysteries of the mind
- Official unveiling of Neuroimaging Centre
- Professor Simon Shorvon appointed Harveian librarian at the Royal College of Physicians
- Parliamentary Group Visit the Institute
- Cultural Consultation Service website launches
- Clinical Teaching Awards 2011/12
- Prestigious European Science Foundation networking grant awarded to Institute of Neurology professor
- International project to determine vascular contribution to neurodegeneration begins
- Prime Minister visits UCL Institute of Neurology
- Professor Ray Dolan gives the prestigious Alan Turing Lecture
- The Performing Brain – A moving story? Friday 16th March
- Are we hard wired to be rebellious?
- Detecting stroke
- Queen Square Clinical Trial Centre launched
- New funding to preserve unique archives
- Major new funding for research into epilepsy is announced
- Professor Ray Dolan elected Fellow of the APS
- New Years Honours
- Brain Implant Cures Woman's Tourette's Tics
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Skin patch improves attention span in stroke patients
4 July 2012
Researchers in the Department of Brain Repair and Rehabilitation have found that giving the drug rotigotine as a skin patch can improve inattention in some stroke patients.
Hemi-spatial neglect, a severe and common form of inattention that can be caused by brain damage following a stroke, is one of the most debilitating symptoms, frequently preventing patients from living independently. When the right side of the brain has suffered damage, the patient may have little awareness of their left-hand side and have poor memory of objects that they have seen, leaving them inattentive and forgetful. Currently there are few treatment options.
The randomised control trial took 16 patients who had suffered a stroke on the right-hand side of their brain and assessed to see whether giving the drug rotigotine improved their ability to concentrate on their left-hand side. The results showed that even with treatment for just over a week, patients who received the drug performed significantly better on attention tests than when they received the placebo treatment.
Rotigotine acts by stimulating receptors on nerve cells for dopamine, a chemical normally produced within the brain.
Professor Masud Husain who led the study at the Institute of Neurology at UCL says: “Inattention can have a devastating effect on stroke patients and their families. It impacts on all aspects of their lives. If the results of our clinical trial are replicated in further, larger studies, we will have overcome a major hurdle towards providing a new treatment for this important consequence of stroke.
“Milder forms of inattention occur in other brain disorders, across all ages - from ADHD (attention deficit hyperactivity disorder) to Parkinson’s disease. Our findings show that it is possible to alter attention by using a drug that acts at specific receptors in the brain, and therefore have implications for understanding the mechanisms that might cause inattention in conditions other than stroke.”
The work, published in the journal Brain, was funded by the Medical Research Council (MRC) and Wellcome Trust.
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Brain (2012) : aws154 doi: 10.1093/brain/aws154 First published online: July 2, 2012. The effects of the dopamine agonist rotigotine on hemispatial neglect following stroke. Nikos Gorgoraptis et al.
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