2009 IoN News Archive
- Grant for research into new epilepsy treatments
- Professor Martin Rossor has been recognised by the The Alzheimer's Association
- Drug discovery collaboration on inclusion body myositis
- PDS awards Training Fellowship to Institute of Neurology researcher to understand how the brain controls Parkinson’s symptoms
- Alan Thompson to lead UCL Partners Neurological Disorders theme
- World MS Day - Wednesday 27th May - Global initiative to highlight Multiple Sclerosis
- Queen Square leads on new UK recommendations for bladder management which can dramatically improve quality of life in Multiple Sclerosis
- John Hardy most-cited Alzheimer's disease researcher in the UK
- Prestigious awards for Institute researchers
- Drug study offers hope for Alzheimer’s treatment
- Brain activity predicts our choices
- Professor George du Boulay CBE, FRCR, FRCP
- Brain awareness week: the impact of UCL research
- Parkinson's-linked mutation makes neurons vulnerable to calcium-induced death
- Second round of NIHR Senior Investigators announced
- 'Mind-Reading' Experiment Highlights How Brain Records Memories
- Anti-malaria drug does not appear to help with human prion diseases.
- UCL Partners is one of UK’s first Academic Health Science Centres
- "Opening doors for patients with MS"
- Are we as decisive as we think?
- "Magnets stop the nightmare of tinnitus, researchers say."
- Prestigious award for Professor Hugh Bostock
- Untangling the Brain
- Young UCL Investigator Award in neuroimaging techniques
- Brain disease "resistance gene" could offer insights into CJD
- Neurology: A Queen Square Textbook
- Headache: annual evidence update
- Roads closed for powerful MRI scanner delivery
- Long-term risks lower for surgical treatment of carotid stenosis
- Memorandum of collaboration signed
- Professor John Hardy joins the ranks of science greats
- Drug study offers hope for Alzheimer's treatment
- Prestigious award for Professor David Miller
- Magnets stop the nightmare of tinnitus, researchers say.
- Brain activity predicts our choices
- Jon Driver Award
- Professor Sander named recipient of the American Epilepsy Society 2009 Clinical Science Award
- Study highlights effect of brain waves on human behaviour
- New podcast describes the significance and impact of highly cited paper
- NIH Grant for research into inherited neuropathies
- How the brain knows a dog is a dog: concept acquisition in the human brain
- Prof Elizabeth Fisher elected member of the European Molecular Biology Organization (EMBO)
- Locating literacy in the brain
- Dopamine enhances expectation of pleasure in humans
- Queen Square scientists question memory theory
- IoN scientist to front Alzheimer’s Research Trust national appeal
- New doors open to the understanding of the origin of brain tumours
Published: Jul 8, 2013 2:00:00 PM
Published: Jul 5, 2013 5:29:00 PM
Neurodevelopmental, neurodegenerative and neuromuscular disorders associated with defective autophagy
Published: Jun 18, 2013 4:38:00 PM
Published: Jun 10, 2013 4:35:00 PM
Brain activity predicts our choices
26 March 2009
Dr Sharot, a British Academy postdoctoral fellow at the Wellcome Trust Centre for Neuroimaging at UCL, has showed that when people rate options similarly, they will choose the one that causes more activation in the caudate nucleus, a brain region involved in anticipating reward.The study also demonstrated that after a decision is made, caudate nucleus activity increases for the selected option and decreases for the rejected one. The findings help to explain a classic finding in psychology.
In 1956, psychologists showed that after choosing between two similar home appliances, women subsequently claimed that the one they picked was better and the one they rejected was worse than they originally thought. In the current study, the researchers used functional brain imaging to explain why people reevaluate their options after making decisions. The research team included UCL’s Professor Ray Dolan, the director of the centre, and Benedetto De Martino.
The researchers imaged people’s brains as they imagined taking holidays in 80 different destinations around the world. After rating how much they would like to travel to each location, participants were asked to decide between similarly rated options — for example, Greece or Thailand. Participants then imagined and rated each location again.
Participants tended to choose the location that most activated the caudate nucleus. In fact, the researchers found that this brain activity could predict where the subjects chose to vacation, even when thoughts of both options were similarly pleasurable.
Consistent with the original psychology study, participants changed their evaluation of the destinations within minutes of making their decisions. For example, if they chose Greece over Thailand, they rated Greece higher and Thailand lower after the decision was made.
The researchers found that activation in the caudate nucleus changed in parallel with this reevaluation. Compared with the initial brain scans, caudate nucleus activation increased for the selected (Greece) and decreased for the rejected (Thailand) option. The findings suggest a biological basis for post-choice reevaluation.
Dr Tarot said: “Re-evaluating our options post-choice may serve an adaptive purpose by increasing an individual’s commitment to the action taken. In the absence of a rapid update of value that concurs with choice, we are likely to second-guess our decisions and actions.”
>> reference: The Journal of Neuroscience, March 25, 2009, 29(12):3760-3765; doi:10.1523/JNEUROSCI.4972-08.2009. How Choice Reveals and Shapes Expected Hedonic Outcome.
Tali Sharot Benedetto De Martino and Raymond J. Dolan