2009 IoN News Archive
- Grant for research into new epilepsy treatments
- Professor Martin Rossor has been recognised by the The Alzheimer's Association
- Drug discovery collaboration on inclusion body myositis
- PDS awards Training Fellowship to Institute of Neurology researcher to understand how the brain controls Parkinson’s symptoms
- Alan Thompson to lead UCL Partners Neurological Disorders theme
- World MS Day - Wednesday 27th May - Global initiative to highlight Multiple Sclerosis
- Queen Square leads on new UK recommendations for bladder management which can dramatically improve quality of life in Multiple Sclerosis
- John Hardy most-cited Alzheimer's disease researcher in the UK
- Prestigious awards for Institute researchers
- Drug study offers hope for Alzheimer’s treatment
- Brain activity predicts our choices
- Professor George du Boulay CBE, FRCR, FRCP
- Brain awareness week: the impact of UCL research
- Parkinson's-linked mutation makes neurons vulnerable to calcium-induced death
- Second round of NIHR Senior Investigators announced
- 'Mind-Reading' Experiment Highlights How Brain Records Memories
- Anti-malaria drug does not appear to help with human prion diseases.
- UCL Partners is one of UK’s first Academic Health Science Centres
- "Opening doors for patients with MS"
- Are we as decisive as we think?
- "Magnets stop the nightmare of tinnitus, researchers say."
- Prestigious award for Professor Hugh Bostock
- Untangling the Brain
- Young UCL Investigator Award in neuroimaging techniques
- Brain disease "resistance gene" could offer insights into CJD
- Neurology: A Queen Square Textbook
- Headache: annual evidence update
- Roads closed for powerful MRI scanner delivery
- Long-term risks lower for surgical treatment of carotid stenosis
- Memorandum of collaboration signed
- Professor John Hardy joins the ranks of science greats
- Drug study offers hope for Alzheimer's treatment
- Prestigious award for Professor David Miller
- Magnets stop the nightmare of tinnitus, researchers say.
- Brain activity predicts our choices
- Jon Driver Award
- Professor Sander named recipient of the American Epilepsy Society 2009 Clinical Science Award
- Study highlights effect of brain waves on human behaviour
- New podcast describes the significance and impact of highly cited paper
- NIH Grant for research into inherited neuropathies
- How the brain knows a dog is a dog: concept acquisition in the human brain
- Prof Elizabeth Fisher elected member of the European Molecular Biology Organization (EMBO)
- Locating literacy in the brain
- Dopamine enhances expectation of pleasure in humans
- Queen Square scientists question memory theory
- IoN scientist to front Alzheimer’s Research Trust national appeal
- New doors open to the understanding of the origin of brain tumours
Published: Jul 8, 2013 2:00:00 PM
Published: Jul 5, 2013 5:29:00 PM
Published: Jun 5, 2013 3:54:00 PM
Published: Jun 5, 2013 2:24:00 PM
Drug study offers hope for Alzheimer's treatment
14 April 2009
As reported in the Times by Mark Henderson: "A new approach to treating Alzheimer’s came closer when a drug was shown in tests to clear the brain of a damaging protein
A new approach to treating Alzheimer’s passed its first clinical test when a drug developed by scientists was shown to clear the brain of a damaging protein linked to the disease.
The drug completely removed a protein called SAP from the brains of five Alzheimer’s patients, suggesting that it may be a potential therapy for the incurable degenerative condition.
While the study was not designed to investigate whether the drug had therapeutic benefits, its results were so promising that the scientists behind it are now seeking up to £4 million to test it on a larger group.
“There is a severe need for a treatment for Alzheimer’s, and there is nothing available that works well,” said Mark Pepys, of University College London, who is leading the research. “Nothing else looks promising at the moment, and this is a pretty good, safe option. We can’t guarantee it will work, but it’s got a good shot.”
The drug, known as CPHPC, was first developed by Professor Pepys almost ten years ago as a possible treatment for amyloidosis, a disease in which amyloid proteins accumulate in the body’s organs, often with fatal results. While Professor Pepys is still investigating the drug for this purpose, and has signed a deal with GlaxoSmithKline to develop it, he is also pursuing it as a possible Alzheimer’s therapy.
Alzheimer’s also features the build-up of amyloid plaques, in this case in brain cells, making CPHPC a good candidate for treatment.
In the new study, published in Proceedings of the National Academy of Sciences, CPHPC was given to patients aged between 53 and 67 who had mild to moderate Alzheimer’s disease. After three months the drug cleared all SAP from their brains. The study was too short to show whether this had any clinical effect but none of the patients deteriorated during the research period.
“The complete disappearance of SAP could not have been confidently predicted, and the drug, also to our surprise, entered the brain,” Professor Pepys said. Martin Rossor, of UCL Institute of Neurology, who also worked on the research, said: “The safety of CPHPC, together with the novel action of the drug in removing SAP, is very encouraging.”
reference >>Molecular dissection of Alzheimer’s disease neuropathology by depletion of serum amyloid P component
Simon E. Kolstoe, Basil H. Ridha, Vittorio Bellottia, Nan Wang, Carol V. Robinson, Sebastian J. Crutch, Geoffrey Keir, Riitta Kukkastenvehmas, J. Ruth Gallimore, Winston L. Hutchinson, Philip N. Hawkins, Stephen P. Wood, Martin N. Rossor, and Mark B. Pepys.