2009 IoN News Archive
- Grant for research into new epilepsy treatments
- Professor Martin Rossor has been recognised by the The Alzheimer's Association
- Drug discovery collaboration on inclusion body myositis
- PDS awards Training Fellowship to Institute of Neurology researcher to understand how the brain controls Parkinson’s symptoms
- Alan Thompson to lead UCL Partners Neurological Disorders theme
- World MS Day - Wednesday 27th May - Global initiative to highlight Multiple Sclerosis
- Queen Square leads on new UK recommendations for bladder management which can dramatically improve quality of life in Multiple Sclerosis
- John Hardy most-cited Alzheimer's disease researcher in the UK
- Prestigious awards for Institute researchers
- Drug study offers hope for Alzheimer’s treatment
- Brain activity predicts our choices
- Professor George du Boulay CBE, FRCR, FRCP
- Brain awareness week: the impact of UCL research
- Parkinson's-linked mutation makes neurons vulnerable to calcium-induced death
- Second round of NIHR Senior Investigators announced
- 'Mind-Reading' Experiment Highlights How Brain Records Memories
- Anti-malaria drug does not appear to help with human prion diseases.
- UCL Partners is one of UK’s first Academic Health Science Centres
- "Opening doors for patients with MS"
- Are we as decisive as we think?
- "Magnets stop the nightmare of tinnitus, researchers say."
- Prestigious award for Professor Hugh Bostock
- Untangling the Brain
- Young UCL Investigator Award in neuroimaging techniques
- Brain disease "resistance gene" could offer insights into CJD
- Neurology: A Queen Square Textbook
- Headache: annual evidence update
- Roads closed for powerful MRI scanner delivery
- Long-term risks lower for surgical treatment of carotid stenosis
- Memorandum of collaboration signed
- Professor John Hardy joins the ranks of science greats
- Drug study offers hope for Alzheimer's treatment
- Prestigious award for Professor David Miller
- Magnets stop the nightmare of tinnitus, researchers say.
- Brain activity predicts our choices
- Jon Driver Award
- Professor Sander named recipient of the American Epilepsy Society 2009 Clinical Science Award
- Study highlights effect of brain waves on human behaviour
- New podcast describes the significance and impact of highly cited paper
- NIH Grant for research into inherited neuropathies
- How the brain knows a dog is a dog: concept acquisition in the human brain
- Prof Elizabeth Fisher elected member of the European Molecular Biology Organization (EMBO)
- Locating literacy in the brain
- Dopamine enhances expectation of pleasure in humans
- Queen Square scientists question memory theory
- IoN scientist to front Alzheimer’s Research Trust national appeal
- New doors open to the understanding of the origin of brain tumours
New doors open to the understanding of the origin of brain tumours
7 December 2009
New research reveals that stem cells in the brain can turn to brain cancer.
Normally, adult brain stem cells form more mature cells such as nerve cells (neurones) astrocytes (supporting cells) or oligodendrocytes (myelin forming cells that wrap around processes of neurones). Researchers at the Division of Neuropathology at UCL Institute of Neurology have shown that different mutations in the stem cells turn them into different types of brain cancer.
Professor Sebastian Brandner, head of the Division of Neuropathology, who led this research in collaboration with Dr Thomas Jacques at UCL Institute of Child Health and scientists at University of California San Francisco (UCSF, USA) said:
"This finding is absolutely novel in the field if brain cancer research. It opens new doors to the understanding of the origin of brain tumours and what influences their behaviour. We now understand better how these tumours form and we can investigate further what leads from a rogue stem cell to a brain tumour. This model will give us new opportunities to develop strategies to fight brain cancer. "
Studies are underway to translate this model system towards a therapy platform for human brain cancers.
The study was published in the EMBO Journal on 19 November 2009
Reference: Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. Thomas S Jacques, Alexander Swales, Monika J Brzozowski, Nico V Henriquez, Jacqueline M Linehan, Zaman Mirzadeh, Catherine O' Malley, Heike Naumann, Arturo Alvarez-Buylla and Sebastian Brandner; The EMBO Journal advance online publication 19 November 2009; doi:10.1038/emboj.2009.327
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