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Research
The centre is involved in the following research areas:
1 - Pathophysiology of critical illness
- mitochondrial dysfunction in critical illness
- association between autonomic and immune dysfunction and relationship to postoperative complications
- mechanisms of acute renal injury (P2X7 receptor activation)
- nitrite reductase activity in sepsis and hypoxaemia
2 - Novel monitoring and diagnostics
- tissue PO2 monitoring as a marker of local oxygen supply adequacy in shock states
- NADH redox state as a marker of the adequacy of tissue perfusion
- novel haemodynamic monitoring parameters using linked oesophageal Doppler ultrasound and blood pressure monitoring
- novel biomarkers for early detection of sepsis and infection
- development of a critical illness stress index
3 - Novel interventions
- long-acting sulphide donor therapy for ischaemia-reperfusion injury
- beta-blocker therapy in severe sepsis
- activators of mitochondrial biogenesis to enhance recovery from critical illness
- CD73 therapy for acute lung injury
- patient-individualized targeted mobilization
