Centre for Intensive Care Medicine
Intensive Care Medicine is part of the Division of Medicine

Medicine News

Research Retreat 2014 - 6th June - deadline for abstracts 28th April

Published: Apr 11, 2014 11:08:00 AM

UCL Applied Renal Physiology 2014 - course

Published: Apr 3, 2014 10:08:20 AM

Rosetrees Trust Studentships - September 2014

Published: Mar 24, 2014 9:39:50 AM

Current research areas

(1) Pathophysiology of critical illness

• mitochondrial dysfunction in critical illness
• association between autonomic and immune dysfunction and relationship to postoperative complications
• mechanisms of acute renal injury (P2X7 receptor activation)
• nitrite reductase activity in sepsis and hypoxaemia

(2) Novel monitoring and diagnostics

• tissue PO2 monitoring as a marker of local oxygen supply adequacy in shock states
• NADH redox state as a marker of the adequacy of tissue perfusion
• novel haemodynamic monitoring parameters using linked oesophageal Doppler ultrasound and blood pressure monitoring
• novel biomarkers for early detection of sepsis and infection
• development of a critical illness stress index

(3) Novel interventions

• long-acting sulphide donor therapy for ischaemia-reperfusion injury
• beta-blocker therapy in severe sepsis
• activators of mitochondrial biogenesis to enhance recovery from critical illness
• CD73 therapy for acute lung injury
• patient-individualized targeted mobilization

 (4) Clinical studies

See separate page