Centre for Intensive Care Medicine
Intensive Care Medicine is part of the Division of Medicine
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Medicine News

Rachel McKendry wins UCL Provost's Spirit of Enterprise 2015 award

Published: Jun 25, 2015 2:25:22 PM

Wellcome Image Award 2015

Published: May 8, 2015 12:08:14 PM

Newton Advanced Fellowship

Published: May 8, 2015 12:08:32 PM

Current research areas

(1) Pathophysiology of critical illness

• mitochondrial dysfunction in critical illness
• association between autonomic and immune dysfunction and relationship to postoperative complications
• mechanisms of acute renal injury (P2X7 receptor activation)
• nitrite reductase activity in sepsis and hypoxaemia

(2) Novel monitoring and diagnostics

• tissue PO2 monitoring as a marker of local oxygen supply adequacy in shock states
• NADH redox state as a marker of the adequacy of tissue perfusion
• novel haemodynamic monitoring parameters using linked oesophageal Doppler ultrasound and blood pressure monitoring
• novel biomarkers for early detection of sepsis and infection
• development of a critical illness stress index

(3) Novel interventions

• long-acting sulphide donor therapy for ischaemia-reperfusion injury
• beta-blocker therapy in severe sepsis
• activators of mitochondrial biogenesis to enhance recovery from critical illness
• CD73 therapy for acute lung injury
• patient-individualized targeted mobilization

 (4) Clinical studies

See separate page