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The second follow-up questionnaire is being mailed to trial participants during April 2014.

For a replacement questionnaire / Freepost envelope please email your details including your UKCTOCS volunteer reference number to ukctocs@ucl.ac.uk
We are aware that the Freepost envelope is “compact”. Please use sticky-tape to seal the envelope if you have concerns.
We confirm that we are employing KGS to capture the data due to the large number of completed questionnaires that we anticipate will be returned. KGS have met and comply with all of our stringent data protection and confidentiality requirements. 

UKCTOCS contact number 0203 447 2125.

Ovarian cancer is the leading cause of death from gynaecological cancers in the United Kingdom. Majority of the women are diagnosed with bulky disease that has spread beyond the ovary and 60% die within five years of diagnosis.

This has led to efforts to try and detect the disease earlier before it has spread. The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) aims to answer the question as to whether screening can save lives.

In this trial over 1.2 million women were invited and 202,638, postmenopausal women aged 50 and above were recruited through thirteen centres in England, Wales and Northern Ireland between 2001 and 2005.

They were randomly assigned to two groups – (1) control group (101,359) who received no screening (to reflect the current situation in the UK) and (2) screen group who had annual screening till December 2011.

The women were screened using two tests - (1) those in the multimodal group (50,640) had a blood test for CA125, a protein which is raised in ovarian cancer.

A mathematical formula called the Risk of Ovarian Cancer algorithm then assigned risk depending of the CA125 trend.

If risk was classified as intermediate or elevated, the volunteer underwent repeat blood tests or a scan. (2) women in the ultrasound group (50,639) had an internal (transvaginal) ultrasound scan of the ovaries.

If an abnormality was seen, the scan was repeated. In both groups women had more extensive testing with referral for surgery if there was persistent abnormality. All participants were followed up for health outcomes using postal questionnaires as well as tracked through the Health and Social Care Information Centre for cancer registrations and deaths.

The preliminary results show that screening has encouraging sensitivity for picking up ovarian cancer.

In 2014-15, the main outcome (did less women die from ovarian cancer in the screen when compared to control group) will be analysed.

ukmap
ISRCTN Number 22488978
UKCRN ID 786

Funding

MRC - Medical Research Council
NHS R&D - National Health Service Research and Development
Medical Research Council
Department of Health
Cancer Research UK
The Eve Appeal
Cancer Research UK The Eve Appeal

Design / Intervention

Randomised controlled trial with three arms:

  1. A control group (no screening).
  2. A multimodal group (annual screening with serum CA 125 as the primary test and CA125 and ultrasound as the secondary test).
  3. An ultrasound group (annual screening with ultrasound as the primary test and repeat ultrasound in 6-8 weeks as the secondary test).

Objectives / Aims

Objective 1

  • To establish the impact of screening on ovarian cancer mortality

Objective 2

  • To determine the physical morbidity of ovarian cancer screening.
  • To determine the resource implications of screening.
  • To record the psychological consequences of screening.
  • To assess the feasibility of population screening for ovarian cancer as reflected by uptake of invitations and compliance rates with annual screening.
  • To compare the performance of two screening strategies for ovarian cancer

Objective 3

  • To establish a serum bank for future assessment of novel tumour markers.

Primary outcome

Ovarian cancer mortality at 7 years after randomisation.

Inclusion / Exclusion Criteria

Inclusion criteria

  1. Age 50-74 years:
  2. Postmenopausal: Either (a) >12 months amenorrhoea following a natural menopause or hysterectomy, or (b) >12 months of hormone replacement therapy (HRT) commenced for menopausal symptoms.

Exclusion criteria

  1. History of bilateral oophorectomy.
  2. Currently active non-ovarian malignancy. Women who have a past history of malignancy will only be eligible if (a) they have no documented persistent or recurrent disease and (b) have not received treatment for >12 months.
  3. Women who have had an ovarian malignancy in the past.
  4. Women at high risk of ovarian cancer due to familial predisposition as defined by the eligibility criteria for the UKCCCR Familial Ovarian Cancer Screening Study.
  5. Women participating in other ovarian cancer screening trials

Recruitment

  • 1,243,282 women aged 50-74 identified from Heath Authority age/sex registers were invited between April 2001 and September 2005.
  • 205,090 women attended for recruitment.
  • 202,638 were randomised

    • 101,359 to control arm.
    • 50,640 to multimodal screening.
    • 50,639 to ultrasound screening.

Screening

Women allocated to the screen arms underwent 7-11 annual screens between April 2001 and December 2011.

Biobank

  1. Over 500,000 serum samples (single sample taken at recruitment for all 3 groups and then annual serial sample taken from multimodal group
  2. Over 350,000 examination transvaginal ultrasound DICOM images

Trial duration

Routine annual screening: April 2001 - December 2011

Follow-up: Till 2018

Primary outcome analysis: 2014

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Principal Investigators

Professor Ian Jacobs University College London / University of Manchester

Professor Usha Menon

University College London

Co-Investigators

Professor Mahesh Parmar MRC Clinical Trials Unit
Professor Steven Skates Harvard Medical School
Professor Stuart Campbell Create Health
Professor Alistair McGuire LSE Health and Social Care
Professor Lesley Fallowfield Cancer Research UK Sussex Psychosocial Oncology

Coordinating Centre Research Team

Contact Telephone: 020 3447 2125

Dr Tindie Kalsi
Project Manager
Dr Andy Ryan Data Manager
Ms Susan Davies Senior Research Sister
Dr Aleksandra Gentry-Maharaj Senior Research Associate and Safety Officer
Dr Sophia Apostolidou Research Associate
Dr Matthew Burnell Statistician
Mr Robert Liston Senior Software Analyst
Dr Anne Dawnay Consultant Clinical Biochemist
Eur Ing Will Stott Creator of Ultrasound Record Archive / Researcher
Dr Aarti Sharma Clinical Research Associate
Dr Mariam Habib Research Associate
Mrs Gwendolen Fletcher National Lead sonographer
Karen Sibley Project Co-ordinator
Dr Rachel Hallett Research Associate
Sara Lewis Research Associate
Susie Grant Research Associate
Lanre Odunlami Software Analyst
Fiona Warburton Statistician

Admin Team

Sheila Spicer
Receptionist/Administrator
Katharine Bailey Administrator
Jennifer Sheals Administrator
Lucy Connelly Administrator
Tracy Roberts Admin support
Yvonne Wold Secretary/Administrator
Charlotte Spicer Administrator
Lisa Hinton Administrator
Althea Dyer Administrator

Laboratory Team

Richard Gunu BMS1
Kirstin Tamm Laboratory technician
Mumtaz Ahmed Laboratory technician
Josephine Cunningham Laboratory technician
Jeremy Ford Laboratory Manager
Theresa Goodall Laboratory technician
Nuno Alves Laboratory technician
Mary Pamboris Laboratory technician
Tasmin Akbar Laboratory technician
Linda Hadcocks Laboratory Manager
Martin Bacon Laboratory technician

Belfast

UKCTOCS Department
93 Lisburn Road
Belfast City Hospital
Belfast, BT9 7BD
Start Date: 11-03-2002
Recruitment: 13,584
Research Nurse / Co-ordinator
Adrina O'Donnell
Research Nurse / Phlebotomist Stevie Marley
Phlebotomist Margaret Young
Lead Radiographers Adneska Zawislak
Principal Investigator Stephen Dobbs

Bristol

Directorate of Obstetrics Gynaecology and ENT
St. Michael's Hospital
Southwell Street
Bristol, BS2 8EG
Start Date: 24-10-2001
Recruitment: 16,538
Research Trial Manager/Phlebotanist
Carole Shahin
Associate Nurse Lizzie Langdon
Sonographers    K.Mc Millen
Sally Sizer
Verity John Katherine Gale
Fiona Anderson
Principal Investigator John Murdoch

Cardiff (University of Wales College of Medicine)

Department of Obstetrics and Gynaecology
Heath Park
Cardiff CF14 4XN
Start Date: 22-04-2002
Recruitment: 16,758
Research Sister Debbie Williams
Ultrasonographers H. Clarke,A. Rogers
S.Underwood
R .Jones
Clerical Officer Gaynor Alexander
Principal Investigator Nazar Amso

Derby

Ovarian Screening Department
Derby City General Hospital
Uttoxeter Road
Derby, DE22 3NE
Start Date: 16-09-2002
Recruitment: 14,920
Research Nurse
Samantha Crockett
Clerk A Ferguson
Consultant Radiographer Gillian Turner
Principal Investigator HowardJenkins

Gateshead

Northern Gynaecological Oncology Centre
Queen Elizabeth Hospital
Sheriff Hill
Gateshead
Tyne & Wear, NE9 6SF
Start Date: 18-04-2001
Recruitment: 17,323
Research Nurse
Rachel Mugnai
Clerk Grace Rudge
Principal Investigator Keith Godfrey

Liverpool

Liverpool Womens Hospital
Crown Street
Liverpool, L8 7SS
Start Date: 16-07-2001
Recruitment: 10,097
Research Nurse
Joyce Ward
Principal Investigators
Johnathon Herod

London - Royal Free

Ovarian Screening Unit
5th Floor - Royal Free Hospital
Pond Street
London, NW3 2QG
Start Date: 22-10-2001
Recruitment: 16,830
Research Nurse
Laura Crosby
Clerk Sally Martin
Phlebotomist Sadhna Bhola
Ultrasonographers Beena Heyer
Elaine Ferrier
Anne Marie Mackins
Principal Investigator Tim Mould

London - St Barts

Ovarian Cancer Screening
Women's Outpatients - 2nd floor Main Outpatients
St. Bartholomew's Hospital
London EC1A 7BE
Start Date: 17-06-2001
Recruitment: 19.834
Research Nurse
Laura Crosby
Clerk Sally Martin
Phlebotomist Sadhana Bohla
Ultrasonographers Elaine Ferrier
Vera Medic
Principal Investigators David Oram

Manchester

The Wellcome Trust Clinical Research Facility
Manchester Royal Infirmary
Grafton Street
Manchester, M13 9WL
Start Date: 10-06-2002
Recruitment: 16,518
Research Nurse Trish Morgan
Associate Nurse Pavenjit Nandhra
Melanie Dadkha -Taeidy
Clerks Suzanne Heywood
Susan Gray
Jennifer Chileshe
Consultant Radiologist Dr Jane Hawnauer
Principal Investigator Mr Mourad Seif

Middlesbrough

Ovarian Screening Office
James Cook University Hospital
Marton Road
Middlesbrough
Cleveland TS4 3BW
Start Date: 10-02-2003
Recruitment: 9,926
Radiographers

Vanessa Chadwick
Louise Prentis

Principal Investigator Derek Cruikshank

N. Wales - Llandudno

Llandudno General Hospital
Llandudno
Wales, LL30 1LB
Start Date: 27-05-2002
Recruitment: 14,338
Research Nurses
Denise Longley & Carol Chapman
Clerk Sandra Huffen
Ultrasonographer Sue Hogg
Principal Investigator Simon Leeson

Nottingham

Nottingham City Hospital Trust Hucknall Road Nottingham, NG5 1PB Start Date: 23-07-2001
Recruitment: 16,781
Administrator
Elaine Bailey
Phlebotomists Cheryl Hewitt
Nicole ward
Chief Radiologist Cathy Bown
Principal Investigator Karin Williams

Portsmouth

Blendworth One, West Wing Corridor
St. Mary's Hospital
Milton Road
Portsmouth, PO3 6AD
Start Date: 11-09-2001
Recruitment: 19,191
Research Nurse
Mary Anderson
Phlebotomist Julie Pryke
Clerk June Burns
Data co-ordinator Caroline West
Principal Investigator Rob Woolas

Trial Steering Committee

Name
Role
Affiliation
Professor David Luesley (Chair) Independent Chairman Professor of Gynaecological Oncology, Birmingham
Professor Jack Cuzick Independent Member Head of Mathematics and Statistics (Cancer Research UK)
Professor Julietta Patnick Independent Member Director, NHS Cancer Screening Programmes
Ms Louise Bayne Lay Representative Director, Ovacome
Ms Jane Sinclair NIHR Representative NIHR Evaluation, Trials and Studies
Coordinating Centre (NETSCC)
Dr Fiona Reddington Cancer Research UK Representative Head of Population Research Funding at Cancer Research UK
Professor Ian Jacobs Director and Principal Investigator Professor and Head of Obstetrics and Gynaecology, Bart's, London
Professor Max Parmar Co - Investigator Head, Cancer Division, MRC Clinical Trials Unit
Professor Lesley Fallowfield Principal Investigator
(Psychosocial Study)
Director, Sussex Psychosocial Oncology Group (Cancer Research UK)
Professor Usha Menon Trial Coordinator/ Co-investigator Head of Gynaecological Cancer Research Centre, Institute of Women's Health, UCL

DMEC Committee

Name Affiliation
Professor Peter Boyle, FRSE (Chair)
President
International Prevention Research Institute
Lyon, France
Dr Susanne Kjaer, MD., DMSc. Head of Department
Dept. of Virus, Hormones and Cancer
Institute of Cancer Epidemiology
Danish Cancer Society
Copenhagen
Professor Dr A. P. M. Heintz Department Obstetrics and Gynaecology
University Hospital Utrecht
The Netherlands
Dr Edward L. Trimble, MD MPH Associate Professor
The Johns Hopkins Hospital
Baltimore, Maryland, USA

Trial Management Committee

Name
Role
Professor Ian Jacobs (Chair) Principal Investigator
Professor Usha Menon Co-Investigator / Trial Co-ordinator
Professor Max Parmar Co-Investigator / Trial Statistician
Dr Steve Skates Co-Investigator
Professor Stuart Campbell Co-Investigator
Professor Ali McGuire Co-Investigator
Mr Tim Mould Centre Lead, Royal Free, London
Mr Rob Woolas Centre Lead, Portsmouth
Dr Tindie Kalsi Project Manager
Dr Andy Ryan Data Manager
Dr Aleksandra Gentry-Maharaj Senior Research Associate and Safety Officer
Miss Susan Davies Senior Research Sister
Dr Justine Kilkerr Psychosocial Study Co-ordinator

Ultrasound Sub-committee

Name
Affiliation
Professor Usha Menon (Chair) GCRC, IfWH, UCL
Professor Stuart Campbell Create Health Clinic, London, UK
Mrs Gwendolen Fletcher GCRC, IfWH, UCL
Mr Nazar Amso Department of Obstetrics and Gynaecology, University of Wales College of Medicine, Heath Park,Cardiff, UK
Mr Mourad Seif Academic Unit of Obstetrics and Gynaecology, St. Mary’s Hospital, Manchester, UK
Dr Gillian Turner Department of Imaging, Royal Derby Hospital, Derby, UK
Dr Carol Brunell Department of Clinical Radiology, UCLH, London, UK
Mrs Kathy Ford St Helens and Knowsley NHS Trust Maternity Ultrasound, Whiston Hospital, Prescot,Merseyside,UK
Dr Rani Rangar Northern Gynaecological Oncology Centre, Queen Elizabeth Hospital, Gateshead, UK
Dr Alex Gentry-Maharaj GCRC, IfWH, UCL
Dr Tindie Kalsi GCRC, IfWH, UCL
Dr Andy Ryan GCRC, IfWH, UCL

Outcome Review Committee

Name
Affiliation
Dr Naveena Singh Consultant Pathologist, Barts Health NHS Trust
Dr Liz Banjamin Consultant Pathologist, UCH NHS Trust
Prof Martin Widschwendter Head, Women's Cancer, IfWH, UCL
Ms. Karina Reynolds Consultant Gynaecological Oncologist, Barts Health NHS Trust

PUBLICATIONS

  1. Burford B*, Gentry-Maharaj A*, Graham R*, Allen D, Pedersen JW, Nudelman AS, Blixt |O, Fourkala E-O, Bueti D, Dawnay A, Ford J, Desai R, David L, Trinder P, Acres B, Schwientek T, Gammerman A, Reis CA, Silva L, Osório H, Hallett R, Wandall HH, Mandel U, Hollingsworth MA, Jacobs I, Fentiman I, Clausen H*, Taylor-Papadimitriou J*, Menon U3*, Burchell JM*. Autoantibodies to MUC1 cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer– nested case control study from UKCTOCS and Guernsey cohorts (British Journal of Cancer, in press)
  2. Sharma A, Burnell M, Gentry-Maharaj A, Campbell S, Amso N, Seif MW, Fletcher G, Brunel C, Turner G, Rangar R, Ryan A, Jacobs I, Menon U for United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) Factors Affecting Visualisation of Postmenopausal Ovaries – Descriptive Study from the Multicentre United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) (UOG, in press)
  3. Gentry-Maharaj A*, Sharma A*, Burnell M, Ryan A, Amso NN, Seif MW, Turner G, Brunell C, Fletcher G, Rangar R, Fallowfield L, Campbell S, Jacobs I, Menon U. Acceptance of transvaginal sonography by postmenopausal women participating in the United Kingdom Collaborative Trial of Ovarian Cancer Screening. Ultrasound Obstet Gynecol. 2013 Jan;41(1):73-9.
  4. Pedersen JW*, Gentry-Maharaj A*, Fourkala E-O, Dawnay A, Burnell M, Zaikin A, Pedersen AE, Jacobs I, Menon U**, Wandall H** Early detection of cancer in the general population - a blinded case control study of p53 auto-antibodies in colorectal cancer. Br J Cancer. 2013 Jan 15;108(1):107-14.
  5. Devetyarov D, Nouretdinov I, Burford B, Camuzeaux S, Gentry-Maharaj A, Tiss A, Smith C, Luo Z, Chervonenkis A, Hallett R, Vovk V, Waterfield M, Cramer R, Timms JF, Sinclair J, Menon U, Jacobs I, Gammerman A Conformal predictors in early diagnostics of ovarian and breast cancers. Progress in Artificial Intelligence.Volume 1, Number 3 (2012), 245-257
  6. Sharma A, Apostolidou S, Burnell M, Campbell S, Habib M, Gentry-Maharaj A, Campbell S, Amso N, Seif MW, Fletcher G, Singh N, Benjamin E, Brunell C, Turner G, Rangar R,Godfrey K, Oram D, Herod J, Williamson K, Jenkins H, Mould T, Woolas R,Murdoch J, Dobbs S, Leeson S, Cruickshank D, Fourkala E-O, Ryan A, Parmar M, Jacobs I*, Menon U*. Risk of epithelial ovarian cancer in asymptomatic women with ultrasound-detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS). Ultrasound Obstet Gynecol 2012;40(3):338-44.
  7. Fourkala E-O, Gentry-Maharaj A, Burnell M, Ryan A, Manchanda R, Dawnay A, Jacobs I, Widschwendter M, Menon U. Histological confirmation of breast cancer registration and self-reporting in England and Wales: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening. Br J Cancer 2012;106(12):1910-6.
  8. Sharma A, Gentry-Maharaj A, Burnell M, Fourkala EO, Campbell S, Amso N, Seif MW, Fletcher G, Brunel C, Turner G, Rangar R, Ford K, Ryan A, Jacobs I, Menon U for UKCTOCS. Assessing the malignant potential of ovarian inclusion cysts in postmenopausal women within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a prospective cohort study. Bjog 2012;119(2):207-19.
  9. Hunter M, Gentry-Maharaj A, Lanceley A, Fraser L, Burnell M, Ryan A, Fraser L, Jacobs I, Menon U. Prevalence, frequency and problem rating of hot flushes persist in older postmenopausal women: impact of age, body mass index, hysterectomy, hormone therapy use, lifestyle and mood in a cross-sectional cohort study of 10,418 British women aged 54-65. BJOG : an international journal of obstetrics and gynaecology, 2012. 119(1): p. 40-50
  10. Timms JF, Menon U, Devetyarov D, Tiss A, Camuzeaux S, McCurrie K, Nouretdinov I, Burford B, Smith C, Gentry-Maharaj A, Hallett R, Ford J, Luo Z, Vovk V, Gammerman A, Cramer R and Jacobs I. Early detection of ovarian cancer in samples pre-diagnosis using CA125 and MALDI-MS peaks. Cancer Genomics Proteomics 2011;8(6):289-305.
  11. Burnell M, Gentry-Maharaj A, Ryan A, Apostolidou S, Habib M, Kalsi J, ,Skates S, Parmar M, Jacobs I, Menon U. Impact On Mortality And Cancer Incidence Rates Of Using Random Invitation From Population Registers For Recruitment To Trials. Trials, 2011. 12: p. 61.
  12. Jacobs I, Gentry-Maharaj A, Burnell M, Manchanda R, Singh N, Sharma A, Ryan A, Seif M, Amso NN, Turner G, Brunell C, Fletcher G, Rangar R, Ford K, Godfrey K, Lopes A, Oram D, Herod J, Williamson K, Scott I, Jenkins H, Mould T, Woolas R, Murdoch J, Dobbs S, Leeson S, Cruickshank D, Skates SJ, Fallowfield L, Parmar M, Campbell S, Menon U. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. The lancet oncology, 2011. 12(1): p. 38-48.
  13. Fallowfield L, Fleissig A, Barrett J, Menon U, Jacobs I, Kilkerr J, Farewell V; UKCTOCS Trialists (Collaborators Jacobs I, Menon U, Campbell S, Fallowfield L, Skates SJ, Parmar M, McGuire A, Lopes A, Godfrey K, Oram D, Herod J, Williamson K, Seif M, Scott I, Jenkins H, Mould T, Woolas R, Murdoch J, Dobbs S, Amso NN, Leeson S, Cruickshank D, Luesley D, Cuzick J, Patnick J, Cheng KK, Bayne L, Law K, Finney K, Gentry-Maharaj A, Burnell M, Ryan A, Kalsi J, Davies S, Fletcher G, Apostolidou S, Liston R.) Awareness of ovarian cancer risk factors, beliefs and attitudes towards screening: baseline survey of 21,715 women participating in the UK Collaborative Trial of Ovarian Cancer Screening. Br J Cancer. 2010 Aug 10;103(4):454-61. doi: 10.1038/sj.bjc.6605809. Epub 2010 Jul 20.
  14. Menon U, Gentry-Maharaj A, Hallett R, Ryan A, Burnell M, Sharma A, Davies S, Philpott S, Lopes A, Godfrey K, Oram D, Herod J, Williamson K, Seif M, Scott I, Mould T, Woolas R, Murdoch J, Dobbs S, Amso N, Leeson S, Cruickshank D, McGuire A, Campbell S, Fallowfield L, Singh N, Dawnay A, Skates S, Parmar M, Jacobs I. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). The lancet oncology, 2009. 10(4): p. 327-40.
  15. Menon U, Gentry-Maharaj A, Ryan A, Sharma A, Burnell M, Hallett R, Lewis S, Lopez A, Godfrey K, Oram D, Herod J, Williamson K, Seif M, Scott I, Mould T, Woolas R, Murdoch J, Dobbs S, Amso N, Leeson S, Cruickshank D, McGuire A, Campbell S, Fallowfield L, Skates S, Parmar M, Jacobs I. Recruitment to multicentre trials: lessons from UKCTOCS – Descriptive study BMJ, 2008. 337: p. a2079.
  16. Menon U, Burnell M, Sharma A, Gentry-Maharaj A, Fraser L, Ryan A, Parmar M, Hunter M, Jacobs I. Decline in use of hormone therapy among postmenopausal women in the United Kingdom. Menopause, 2007. 14(3 Pt 1): p. 462-7.
  17. Timms JF, Arslan-Low E, Gentry-Maharaj A, Luo Z, T'Jampens D, Podust VN, Ford J, Fung ET, Gammerman A, Jacobs I, Menon, U. Preanalytic influence of sample handling on SELDI-TOF serum protein profiles. Clinical chemistry, 2007. 53(4): p. 645-56.

Letters to editor

  1. Gentry-Maharaj A, Kalsi J, Burnell M, Manchanda R, Menon U. Screening of symptomatic women for ovarian cancer. Lancet Oncol 2012;13(4):e138-9; author reply e39-40. (Letter to Editor)
  2. Menon U, Gentry-Maharaj A, Jacobs I. Ovarian cancer screening and mortality. JAMA 306(14):1544 (Letter to Editor)

Papers in press

  1. Sharma A, Burnell M, Gentry-Maharaj A, Campbell S, Amso N, Seif MW, Fletcher G, Brunel C, Turner G, Rangar R, Ryan A, Jacobs I, Menon U for United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) Quality Assurance of Transvaginal Scanning in the Multicentre United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) (Submitted to UOG)
  2. Burford B*, Gentry-Maharaj A*, Graham R*, Allen D, Pedersen JW, Nudelman AS, Blixt |O, Fourkala E-O, Bueti D, Dawnay A, Ford J, Desai R, David L, Trinder P, Acres B, Schwientek T, Gammerman A, Reis CA, Silva L, Osório H, Hallett R, Wandall HH, Mandel U, Hollingsworth MA, Jacobs I, Fentiman I, Clausen H*, Taylor-Papadimitriou J*, Menon U3*, Burchell JM*. Autoantibodies to MUC1 cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer– nested case control study from UKCTOCS and Guernsey cohorts (Submitted to British Journal of Cancer)

BOOK CHAPTERS AND REVIEW ARTICLES

  1. Gentry-Maharaj A, Menon U. Screening for ovarian cancer in the general population. Best Pract Res Clin Obstet Gynaecol 2012;26(2):243-56.
  2. Gentry-Maharaj A, Jacobs I, Menon U. (2009) Development and identification of tumor markers. in Principles and Practice of Gynecologic Oncology 5th edition (chapter 7), edited by William J Hoskins, Carlos A Perez, Robert C Young, Richard R Barakat, Maurie Markman
  3. Gentry-Maharaj A, Sharma A, Menon U. Ovarian Cancer. Review article in Geriatric Medicine, Vol 37, No 11, November 2007

CONFERENCES AND MEETINGS

2012

ANNUAL SCIENTIFIC MEETING AND WORKSHOPS, JOINT RCOG/BSGI MEETING, 18 MAY 2012, ROYAL COLLEGE OF OBSTETRICIANS AND GYNAECOLOGISTS, LONDON

  • Gentry-Maharaj A. “Does transvaginal ultrasound have any role in the screening for endometrial cancer in asymptomatic postmenopausal women?” (invited speaker)

8TH INTERNATIONAL WORKSHOP ON ARTIFICIAL INTELLIGENCE APPLICATIONS AND INNOVATIONS

  • Nouretdinov I, , Devetyarov D, Burford B,Camuzeaux S, Gentry-Maharaj A, Tiss A, Smith C, Luo Z, Chervonenkis A, Hallett R, Vovk V, Waterfield M, Cramer R, Timms JF, Jacobs I, Menon U, Gammerman A. Multiprobabilistic Venn predictors with logistic regression ( Conference Paper ) IFIP Advances in Information and Communication Technology (Volume 382 AICT, Issue PART 2, 2012, Pages 224-233, 8th International Workshop on Artificial Intelligence Applications and Innovations, AIAI 2012: AIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMB;Halkidiki;27 September 2012through30 September 2012;Code94333)

NCRI ANNUAL MEETING, OCTOBER 2012, LIVERPOOL

  • Jacobs I, Ryan A, Skates S, Habib M, Apostolidou S, Singh N, Benjamin E, Gentry-Maharaj A, Burnell M, Kalsi J, Dawnay A, Sharma A, Gunu R, Godfrey K, Oram D, Herod J, Williamson K, Seif MW, Jenkins H, Mould T, Woolas R, Murdoch J, Dobbs S, Amso N, Leeson S, Cruickshank D, Fallowfield L, Campbell S, Parmar M, Menon U. for the UKCTOCS Group Performance characteristics of multimodal screening with serum CA125 in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
  • Menon U,  Ryan A, Campbell S, Habib M, Apostolidou S, Gentry-Maharaj A, Burnell M, Kalsi J, Sharma A, Singh S, Benjamin E, Fletcher G, Seif MW, Amso N, Burnel C, Taylor G, Rangar R, Godfrey K, Oram D, Herod J, Williamson K, Jenkins H, Mould T, Woolas R, Murdoch J, Dobbs S, Leeson S, Cruickshank D, Fallowfield L, Parmar M,.Jacobs I for the UKCTOCS Group Performance characteristics of ultrasound screening in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

UCL EGA INSTITUTE FOR WOMEN’S HEALTH ANNUAL MEETING, 21 MAY 2012, LONDON

  • Woolas R, Talaa A, Anderson M, Garner F, Brinkmann D, Ryan A, Gentry-Maharaj A, Kalsi J, Rosenthal A, Menon U, Jacobs I. A prospective study of endometrial thickness >10mm among 3646 women aged 50-80 years undergoing transvaginal ultrasound screening for ovarian cancer
  • Fourkala, E-O, Zaikin A, Burnell M, Gentry-Maharaj A, Jacobs I, Dawnay A, Widschwendter M, Menon U. In postmenopausal women increased levels of testosterone and follicle stimulating hormone are associated with increased breast cancer risk: a nested case-control study within UK Collaborative Trial of Ovarian-Cancer Screening (UKCTOCS)
  • Menon U, Fourkala, E-O, Burnell M, Gentry-Maharaj A, Fraser L, Ryan A, Kalsi JK, Parmar M, Jacobs I, Gessler S, Gidron Y. Association of helplessness-hopelessness and all cause/cancer-specific mortality in postmenopausal women – a prospective cohort study within the control arm of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
  • Kalsi J, Burns L, Ryan A, Fraser L, Ruff L, Philpott S, Johnson M, Habib M, Liston W, Apostolidou S, Fourkala E, Burnell M, Spicer S, Fletcher G, Davies S, Bailey K, Chamberlain S, Iyer R, Balogun N, Desai1 R, Mohamed S, Manchanda R, Gentry-Maharaj A, Parmar M, Fallowfield L, Campbell S, Skates S, Rosenthal A, Jacobs I, Menon U. A Tale of Two Cards
  • O’Brien DP, Sinclair J, Jenkinson C, Gentry-Maharaj A, Menon U, Costello E, Pereira SP, Timms JF. Quantitative Proteomic Strategies for the Discovery and Evaluation of Early Diagnostic Biomarkers for Pancreatic Cancer in Serum (GO)

2011

BRITISH GYNAECOLOGICAL CANCER SOCIETY (BGCS) MEETING, NOVEMBER 2011, BIRMINGHAM

  • Sharma A, Apostolidou S, Burnell M, Habib M, Gentry-Maharaj A, Campbell S, Godfrey K, Oram D, Herod J, Williamson K, Seif MW, Jenkins H, Mould T, Woolas R, Murdoch J, Dobbs S, Amso N, Leeson S, Cruickshank D, Fourkala E-O, Ryan A, Parmar M, Jacobs I, Menon U for United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Risk of primary ovarian cancer in asymptomatic women associated with ovarian morphology on ultrasound: a prospective cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

INTERNATIONAL SOCIETY OF ONCOLOGY AND BIOMARKERS MEETING, 15 TO 19 OCTOBER 2011, FLORENCE

  • Alderton WK, Apostolidou S,  Barnes MR, Fourkala E, Gentry-Maharaj A, Jacobs I, Menon U, Ryan A, Barnes J. Reporting on cancer cases developed in a prospective cohort of volunteers from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS):  Relevance of the associated serum biobank for biomarker discovery and validation

BRITISH SOCIETY FOR PROTEOME RESEARCH, JUNE 2011, CAMBRIDGE

  • O’Brien DP, Sinclair J, Jenkinson C, Gentry-Maharaj A, Menon U, Costello E, Pereira S, Timms JF. Quantitative proteomic strategies for the discovery and evaluation of early diagnostic biomarkers for pancreatic cancer in serum

2010

DIGESTIVE WEEK 2010, NEW ORLEANS

  • Sandanayake NS, Andreola F, Camuzeaux S, Sinclair J, Chapman MH, Webster G, Gentry-Maharaj A, Menon U, Jacobs I, Pereira SP, Timms,JF. Serum CEACAM1 in the preclinical diagnosis of pancreatic adenocarcinoma

2009

BRITISH MEDICAL ULTRASOUND SOCIETY MEETING, 8 DECEMBER 2009, EDINBURGH

  • Gentry-Maharaj A. Presented a talk on “Prevalence Screen in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)”
  • Gentry-Maharaj A. Presented a talk on “Volunteer Satisfaction Survey for UKCTOCS”
  • Poster presentation on “Auditing UKCTOCS ultrasound images to validate the ovary visualisation rates of individual sonographers” Stott W, Ryan A, Gentry-Maharaj A, Fletcher G, Burnell M, Amso N, Seif M, Ferguson A, Turner G, Brunell C, Ford K, Rangar R, Campbell S, Jacobs I, Jones C, Menon U.

SENIOR STAFF CONFERENCE, RCOG, 26 NOVEMBER 2009, LONDON

  • Gentry-Maharaj A. Presented a talk on “Preliminary screening information for UKCTOCS” (official title of talk)

INNOVATIONS & PROGRESS IN HEALTHCARE FOR WOMEN, 2ND INTERNATIONAL MEETING: PREVENTION, SCREENING AND RISK PREDICTION IN WOMEN’S HEALTH, 9 TO 11 NOVEMBER 2009

  • Oral presentation on “Serial CA125 interpreted using the Risk of Ovarian Cancer algorithm can detect ovarian cancer in absence of ultrasound abnormalities”, Menon U, Gentry-Maharaj A, Ryan A, Burnell M, Dawnay A, Habib M, Apostolidou S, Skates S, Parmar M, Jacobs I. (Awarded 1st prize)
  • Oral presentation on “Serum oestrogen receptor-alpha and beta bioactivity are associated with breast cancer risk”  Fourkala E-O, Lichtenberg-Frate H, Burnell M, Gentry-Maharaj A, Hasenbrink G, Ford J, Schawarzer S, Dawnay A, Lam A,  Apostolidou S, Raum E, Stegmaier C, Jacobs I, Brenner H, Widschwendter M, Menon U.
  • Poster presentation on “Completeness of cancer registration and self-reporting of breast cancer in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)” Fourkala E-O, Gentry-Maharaj A, Burnell M, Ryan A, Jacobs I, Widschwendter M, Menon U.
  • Poster presentation on “Auditing UKCTOCS ultrasound images  to validate the ovary visualisation rates of individual sonographers” Stott W, Ryan A, Gentry-Maharaj A, Fletcher G, Burnell M, Amso N, Seif M, Ferguson A, Turner G, Brunell C, Ford K, Rangar R, Campbell S, Jones C, Menon U.

BRITISH SOCIETY FOR GYNAECOLOGICAL IMAGING, MARCH 2009, LONDON

  • Gentry-Maharaj A. Presented a talk on “The Prevalence Screen in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)”

CONTROVERSIES OF OVARIAN CANCER SCREENING, 8 JANUARY 2009, GENEVA, SWITZERLAND

  • Gentry-Maharaj A. Presented a talk on “The Prevalence Screen in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)” (invited talk)

2008

INTERNATIONAL MENOPAUSE SOCIETY MEETING, 19 TO 23 MAY 2008, MADRID

  • Oral presentation on Trends in HRT and non-HRT use in postmenopausal women in the UK. GentryMaharaj A, Ryan A, Brusati L, Nayak N, Burnell M, Sharma A, Lanceley A, Fraser L, Jacobs I, Hunter M, Menon U for UKCTOCS

BECKMAN COULTER SYMPOSIUM, 9 JULY 2008, LONDON

  • Gentry-Maharaj A. Presented a talk regarding the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) (invited talk)

2007

EUROPEAN SOCIETY FOR GYNECOLOGICAL ONCOLOGY (ESGO), 28 OCT TO 1 NOV 2007, BERLIN

  • Poster presentation on Cancer notification: Should data be collected from multiple sources?Gentry-Maharaj A., Burnell M., Ryan A., Hallett R., Sharma A., Parmar M, Jacobs I.J., Menon U. for UKCTOCS
  • Ovarian inclusion cysts – what is their malignant potential? Sharma A, Campbell S, Gentry-Maharaj A, Burnell M, Ryan A, Hallett R, Jacobs IJ, Menon U. for United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
  • Importance of independent review of diagnosis in research trials involving cases of ovarian and primary peritoneal cancerHallett RL, Singh N, Reynolds K, Gentry-Maharaj A, Burnell M, Ryan A, Sharma A, Parmar M, Jacobs IJ, Menon U. for United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
  • Evidence of a healthy volunteer effect in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)Burnell M, Parmar M, Ryan A, Gentry-Maharaj A, Hallett R, Sharma A, Jacobs IJ, Menon U. for UKCTOCS
  • Ovarian cancer serum biomarker discovery using maldi-tof ms proteomic profilingCamuzeaux S., Kabir M., Burford B., Nouretdinov I., Vovk V., Ford J., Luo Z., Gentry-Maharaj A., Waterfield M., Menon U., Gammerman A., Timms J.F.,  Jacobs I.

2006

INTERNATIONAL GYNAECOLOGICAL CANCER SOCIETY (IGCS) MEETING, 14 TO 18 OCTOBER 2006, SANTA MONICA

  • Oral presentation on Sensitivity and Specificity of Transvaginal Ultrasound Screening for Endometrial Cancer in 40,000 women from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) Jacobs I, Gentry-Maharaj A, Burnell M, Seif M, Amso N, Campbell S, Menon U for UKCTOCS
  • Poster presentation on Pre-Analytic Influence of Sample Handling on SELDI-TOF Serum Protein Profiles Timms JF, Arslan-Low E, Gentry-Maharaj A, Luo Z, T’Jampens D,  Podust VN, Ford J, Fung ET, Gammerman A, Jacobs I, Menon U
  • Risk of Ovarian Cancer (ROC) algorithm increases specificity of CA125 in ovarian cancer Screening Gentry-Maharaj A, Skates S, Sharma A, Burnell M, Ryan A, Grant S, Ford J, Dawnay A, Parmar M, Jacobs I, Menon U for UKCTOCS (opening session)

INSTITUTE FOR WOMEN’S HEALTH MEETING, DECEMBER 2006, LONDON

  • Oral presentation on Risk of Ovarian Cancer (ROC) algorithm increases specificity of CA125 in ovarian cancer Screening Gentry-Maharaj A, Skates S, Sharma A, Burnell M, Ryan A, Grant S, Ford J, Dawnay A, Parmar M, Jacobs I, Menon U for UKCTOCS (awarded 1st prize)

2005

INSTITUTE FOR WOMEN’S HEALTH, 1ST ANNUAL MEETING, DECEMBER 2005, LONDON

  • Gentry-Maharaj A. Poster presentation on behalf of UKCTOCS Group on the United Kingdom Collaborative trial of Ovarian Cancer Screening (UKCTOCS): Outcome Review Process

EUROPEAN SOCIETY OF GYNAECOLOGICAL ONCOLOGY (ESGO), 25 TO 29 SEPTEMBER 2005, ISTANBUL

  • Gentry-Maharaj A. Poster presentation on behalf of UKCTOCS Group on the United Kingdom Collaborative trial of Ovarian Cancer Screening (UKCTOCS): Outcome Review Process

NATIONAL CANCER RESEARCH INSTITUTE (NCRI) CONFERENCE, 2 TO 5 OCTOBER 2005, BIRMINGHAM

  • Gentry-Maharaj A. Poster presentation on behalf of UKCTOCS Group on the United Kingdom Collaborative trial of Ovarian Cancer Screening (UKCTOCS): Outcome Review Process
  • Burnell M. Poster presentation on behalf of UKCTOCS Group on the Fear of Breast Cancer and Decline of HRT Use in the UKCTOCS Trial
  • Menon U. Poster presentation on behalf of UKCTOCS Group on the Innovative Data Management system in the UKCTOCS Trial
  • Sharma A. Poster presentation on behalf of UKCTOCS Group on Evaluation of Ultrasound Quality in the UKCTOCS Trial

MEDIA COVERAGE

NEWS

Ovarian cancer screening - (NHS News; March 11 2009)
www.nhs.uk/news/2009/03March/Pages/OvarianCancerScreeningTrial.aspx
Trials offer ovarian cancer hope (BBC News Web pages; Wednesday 9 March 2009
news.bbc.co.uk/1/hi/health/7934784.stm
Ovarian cancer screening on trial (The Guardian; Wednesday 22 March 2000; page 7)
www.guardian.co.uk/Archive/Article/0,4273,3976839,00.html
Cancer screening trials to begin (BBC News web pages; Tuesday 21 March 2000)
news.bbc.co.uk/1/hi/health/684131.stm

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