Centre for Inflammation and Tissue Repair



  1. Patel AR, Kowlessar BS, Donaldson GC, Mackay AJ, Singh R, George SN, Garcha DS, Wedzicha JA, Hurst JR. Cardiovascular Risk, Myocardial Injury and Exacerbations of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2013: in press
  2. Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease. Datta A, Alexander R, Sulikowski MG, Nicholson AG, Maher TM, Scotton CJ, Chambers RC. J Immunol. 2013 Sep 30.
  3. Proteinase-Activated Receptor-1, CCL2 and CCL7 Regulate Acute Neutrophilic Lung Inflammation. Mercer PF, Williams AE, Scotton CJ, José RJ, Sulikowski M, Moffatt JD, Murray LA, Chambers RC. Am J Respir Cell Mol Biol. 2013 Aug 23.
  4. C.Hyams, K.Trzcinski, E.Camberlein, D.M.Weinberger, S.Chimalapati, M.Noursadeghi, M.Lipsitch, J.S.Brown. ‘Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of Factor H binding and opsonization with C3b/iC3b. Infection and Immunity 2013;81(1):354-63.
  5. Ex vivo μCT analysis of bleomycin-induced lung fibrosis for pre-clinical drug evaluation. Scotton CJ, Hayes B, Alexander R, Datta A, Forty EJ, Mercer PF, Blanchard A, Chambers RC. Eur Respir J. 2013 Mar 21.
  6. Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE. EMBO Mol Med. 2012 Sep;4(9):939-51.
  7. Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis. Maher TM, Evans IC, Bottoms SE, Mercer PF, Thorley AJ, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, McAnulty RJ. Am J Respir Crit Care Med. 2010 Jul 1;182(1):73-82.
  8. TGF-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. Bottoms SE, Howell JE, Reinhardt AK, Evans IC, McAnulty RJ. PLoS One. 2010 Mar 12;5(3):e9674.
  9. Green, J. A., Elkington, P. T., Pennington, C. J., Roncaroli, F., Dholakia, S., Moores, R. C., Porter JC, Friedland, J. S. (2010).Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks. J Immunol, 184 (11), 6492-6503.
  10. Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, Miller B, Lomas DA, Agusti A, MacNee W, Calverley P, Rennard S, Wouters EFM, Wedzicha JA.  Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease.  New England Journal of Medicine 2010;363:1128-1138
  11. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. Scotton CJ, Krupiczojc MA, Königshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC. J Clin Invest. 2009 Sep;119(9):2550-63.
  12. Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DC, McAnulty RJ, Das A, Thorley AJ, Tetley TD, Eickelberg O, Chambers RC. Am J Respir Crit Care Med. 2009 Mar 1;179(5):414-25.
  13. Porter, J. C., & Hall, A. (2009). Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. FASEB J, 23 (2), 492-502.
  14. Porter, J. C., Falzon, M., & Hall, A. (2008). Polarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression. J Immunol, 180 (3), 1866-1877.
  15. S.Khandavilli, J.Yuste, S.Basavanna, T.Mitchell, J.S.Brown. ‘Maturation of Streptococcus pneumoniae lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence.’ Molecular Microbiology 2008; 67(3): 541-547.
  16. J.Yuste, M.Botto, S.E.Bottoms, and J.S.Brown. ‘Serum Amyloid P Aids Complement Mediated Immunity to Streptococcus pneumoniae.’ PLOS Pathogens, 2007;3(9):e120.