A comprehensive introduction to the immune system. We will start by looking at the various cells and molecules that are involved, and explore their functional organisation. We will ask some basic questions such as how does the immune system know what to respond to?, and how does it eliminate infection?. We will go on to discuss the concept of immunological memory and how vaccination works. Like any complex machine, there are multiple ways in which the immune system can malfunction. Once you have an understanding of the ‘nuts and bolts’ of the immune system, and grasped some of the main concepts behind how it functions in a healthy individual, we will move on to talk about disease situations associated with imbalanced immunity, including immunodeficiencies, allergy and autoimmunity. We will also look at the medically very important field of transplantation, and investigate the potential for the immune system to fight different types of cancer. The module is assessed by a final unseen examination.
Module Tutor: Professor Peter Delves
This module provides a basic foundation in the fascinating and important discipline of infection. Common pathogens, including bacteria, viruses, fungi and parasites are discussed in relation to their biology and the diseases they cause. The focus of the module is pathogenicity: the capacity to cause disease. We will consider: how the immune system provides protection against infection; how pathogens manage to flourish in the face of the formidable array of host protective mechanisms; how vaccines and drugs can be used in the fight against infection. Considerable emphasis will be placed on critical discussion of these core concepts. The module is assessed by a coursework essay.
Module Tutor: Dr Richard Milne
The following modules are available to 3rd year students. See the Common Timetable Block Allocations
INIM3002 Immunology in Health & Disease (Term 1)
Immunology in Health and Disease provides an overview of the human immune system. Starting at the molecular level (e.g. antigen recognition, antibody diversity), outlining what is known about cellular interactions within the immune system (e.g. cytokines and immunoregulation) and concluding with a consideration of the role of the immune system in host defence, its role in disease, and its possible role in determining ecology and evolution of the species. The module will cover the anatomy and constituents of the immune system and then consider the general principle of how an immune response is generated, beginning with the initial innate immune response to the development of acquired immunity. These concepts will be placed in context: how the immune system fights pathogens, how inappropriate responses can cause disease and how the immune system can be manipulated therapeutically. The module will develop from a basic to a more in depth understanding, with emphasis throughout placed on current developments in this fast moving field. The module includes a series of tutorials which provide students with an opportunity to present and discuss current research papers.
Module Tutor: Dr Brian De Souza
INIM3003 Infectious Agents (Term 1)
The Infectious Agents module provides state-of-the-art coverage of a selection of current issues in the field of infection. No attempt is made to cover a comprehensive curriculum but, instead, students will learn the language and concepts of the field through specific research-led examples and active discussions. Themed teaching sessions given by experts comprise an introduction to the topic followed by discussion and critique of a recent paper. Papers will be provided in advance and students will be expected to come to sessions prepared to discuss the set paper critically. In some sessions students will be required to lead discussions. Assessment is a short presentation of a chosen paper and a written commentary based on this. The focus throughout the module is on reading and discussing primary literature: full participation in class discussions is essential.
Module Tutor: Dr Richard Milne
INIM3004 Cellular Pathology (Term 1)
Cellular pathology encompasses the mechanisms by which dysfunction of cellular processes contributes to the pathogenesis of disease. In this module, we aim to give you an in-depth understanding of key cellular processes, to introduce the contemporary experimental approaches that are used to study them and to highlight the mechanisms by which their dysfunction can cause disease. The module is organised to exploit the strengths of teaching in the context of a research-rich university. The topics covered are chosen partly on their importance and partly to reflect the specific research strengths within UCL: all the lectures are given by top researchers in the field. Given the scope of molecular cell biology, the module cannot be comprehensive. Nor is it feasible in a single lecture to exhaustively cover even a single topic (for example the cell cycle). The objectives are to provide: a sufficient basic knowledge of the major processes of the cell; a flavour of what are the outstanding questions driving research in the field at present and how these could be tackled; and to equip students to begin to consider the intricate connection between cellular processes and disease.
Module Tutor: Professor Benny Chain
VIRL3001 Molecular Virology (Term 1)
The aim of the module is to give students an up to date insight into molecular virology, with particular focus on human pathogens and new research developments in the field. Lectures will cover a selection of important human viral pathogens: herpesviruses, retroviruses including HIV, hepatitis viruses, human papilloma viruses and Influenza viruses, chosen to reflect clinical and research expertise within UCL. The molecular aspects of virus replication will also be put in a broader context of disease pathogenesis and therapy, with lectures covering viruses and cancer, emerging viruses, viral immunology antiviral therapy and vaccines.
Module Tutor: Dr Richard Milne
INIM3001 Laboratory-Based Research Project (Term 1 & 2)
This research project module, available only to Infection and Immunity students, aims to give you first-hand experience of original laboratory research under direct supervision of principal investigators at UCL. We assess the aspirations of each student individually to identify their preferences for potential types of project that are relevant to the broad scope of the iBSc. Together with their supervisor, students will then formulate a specific project, design and undertake experiments, and interpret /communicate their work in oral presentations and a written report. This module provides invaluable teaching in scientific methodology, laboratory techniques, critical appraisal of original experimental data, and unique insight into the potential of new discoveries. The skills acquired here provide a competitive platform for students who may wish to pursue a future research or clinical academic career.
Module Tutor: Dr Mahdad Noursadeghi
INIM3005 Immunodeficiency & Therapeutics (Term 2)
The immune system comprises components that are involved in recognition of invading pathogens and other noxious agents, microbial killing and tissue homeostasis/repair. Therefore, deficiencies of the immune system can be associated with increased susceptibility to infectious disease or a failure to control inflammation. The study of immunodeficiencies has in fact contributed extensively to our current understanding of normal structure and function in the immune system, and in turn has led innovative approaches to manipulate immune responses for therapeutic purposes. This module seeks to explore the broad repertoire of both genetic (primary immunodeficiency) and environmental (secondary immunodeficiency) causes of impaired immunity, together with the consequences for the patient of such deficiencies and the insights provided into our understanding of the normal immune system. The treatment options that are available for these will be discussed, as well as approaches to immunomodulation including research which aims to transform gene and cell therapies into clinical applications.
In this module we aim to give you the framework and examples by which:
1. To understand the molecular basis and medical importance of selected humoral and cellular primary immunodeficiency syndromes.
2. To understand contemporary research approaches to investigate the molecular mechanisms that underlie primary immunodeficiencies, with specific examples from recent discoveries.
3. To understand the range of disorders associated with acquired immunodeficiency syndrome, focussing on ageing, pregnancy, nutritional deficiency, HIV infection and iatrogenic causes such as bone marrow transplantation or immunosuppressive medication.
4. To explore how the study of mechanisms for immunodeficiency provide new insights into normal immunology and opportunities to modulate immune responses for therapeutic applications.
5. To obtain an overview of therapies that target the immune system, including biological agents, T cell or DC therapies and advances in vaccination.
Module Tutor: Dr Mahdad Noursadeghi
INIM3006 Allergy, Autoimmunity & Transplantation (Term 2)
This module focuses on disadvantageous immune responses: when the immune system causes disease by mounting undesired responses to allergens, self or transplanted tissues. We will explore the genetics and immune mechanisms underlying these responses and ask why substantial numbers of individuals react in a harmful way to normally ‘harmless’ environmental antigens such as pollens or food. We will consider autoimmunity: the breakdown in the immunological tolerance mechanisms that normally prevent pathogenic responses against our own body constituents. Organ-specific and systemic autoimmune conditions will be covered and the contribution of the various components of the immune system to the destructive process discussed. We will also explore the artificial situation of transplanting an organ or tissue from one individual to another. In addition to looking into the various immunological mechanisms involved in transplant rejection, we will investigate how transplant survival can be further improved and whether the current need for long term immunosuppression after transplantation can be overcome.
Module Tutor: Dr Brian De Souza
INIM3007 Viruses & Disease (Term 2)
What are viruses? How do they replicate? Where do they come from? How do they enter the human population? How do they cause disease? Why do they cause epidemics? Why are some viruses much more dangerous than others? How do we control and prevent infections? This module will address these questions by exploring the remarkable and intimate interaction between virus and host at many levels: molecular, cellular, host organism and population. We will discover how viruses have adapted to optimise survival and replication in the fundamentally hostile environment that their host provides and we will discuss the many effector mechanisms that hosts deploy to prevent viral infection or control it once established.
The module is centred on the idea that an understanding of basic virology is essential for understanding viral disease. Drawing on a major strength in experimental and clinical virology at UCL, the module will provide an advanced understanding of the principles of virus replication and structure, insight into the virus-host interaction and a broad knowledge of individual virus infections, their treatment and prevention.
Module Tutor: Dr Richard Milne
INIM3008 Microbial Pathogenesis (Term 2)
This module focusses on bacterial, fungal and parasitic pathogens that cause human disease. We will consider the role of microbial virulence factors and the host-pathogen interactions that mediate disease and the way that knowledge of these can inform our clinical management strategies.
By the end of the module, students will be able to: describe the major bacterial, fungal and parasitic pathogens; describe the molecular mechanisms by which these pathogens invade and cause disease; explain the molecular pathogenesis of examples of acute and chronic infectious diseases including tuberculosis, malaria, meningitis, gastrointestinal and respiratory infections; provide an overview of the techniques for molecular diagnosis of infection and the tools for molecular epidemiology of infection; describe the mechanisms of host immune evasion.
Module Tutor: Prof Tim McHugh
INIM3009 Neoplasia & its Treatment (Term 2)
This module explores the processes and molecular mechanisms that underpin neoplastic transformation, tumour invasion and metastasis, with reference to specific haematological and solid tumours.
The aim is for the student to build on an assumed core knowledge of cell and molecular biology to understand the natural history of neoplastic disease. There is considerable emphasis on the links between normal growth, development and responsiveness, and neoplastic growth. Site specific aspects of neoplasia (e.g. colon cancer, lung cancer and leukaemia) will be considered. In addition, all these topics will be linked to lectures that explore the mechanisms of current and novel treatment modalities including chemotherapy, biologicals, stem cell transplantation, immunotherapy and gene therapy.
The module starts with an overview of current concepts of normal and abnormal growth, cancer stem cells, cell senescence and immortalisation, invasion and metastasis. We then examine cell transformation at a cellular and molecular level and look at DNA damage and repair mechanisms. The properties of the neoplastic cell are examined critically, looking at oncogenes, growth factors and their receptors and there will be a discussion about chromosome abnormalities in cancer. The link between viral infections and human tumours and the biology of oncogenic viruses and their relationship with the immune system will be explored. To put neoplastic disease in its societal context, epidemiological aspects will be covered in a separate session. There will be lectures on stem cells –an increasingly important topic, not only in our understanding of the basic science of neoplasia, but also with important therapeutic implications.
Malignant tumours are the second most common form of illness leading to death in this country. Treatments include surgery, radiotherapy, hormones and various forms of cytotoxic chemotherapy. The second part of the module will look at the mechanisms which underlie some of these forms of treatment including the molecular basis of anti-cancer drugs and the use of radiation and its effects. We will cover the basic principles of tumour immunity and the potential of immune mechanisms in the prevention, limitation and evolution of tumours. Physical and chemical oncogenic agents or carcinogens have a more subtle relationship with the immune system, and this will be explored. Lastly, the possibility of manipulating immunogenic tumours to the benefit of the individual or of using immunological weapons to attack malignant tumours will be explored, giving an insight into cancer therapies of the future; and this leads into a discussion of the potential advantages and disadvantages of gene therapy for cancer.
Module Tutor: Dr Clare Bennett
Students comments have been collated by Professor Pete Delves and Mrs
Biljana Nikolic and give us a good "end of term" report! Date: July
Module (Lead, Professor Peter Delves): ‘Absolutely awesome. I would definitely recommend it to first year biology students as a useful grounding irrespective of whether or not immunology is a chosen career path. Very well organised too, the course organizer is always very on the ball and this really helps avoid confusion among students.’
Lecturer (Professor Peter Delves): ‘Out of all the lecturers I have had during my exchange year in London, this lecturer was the best. He is very good at teaching, very pedagogic and devoted.’
Module (Lead, Professor Peter Delves): ‘I thought the teaching has been quite phenomenal and I've been greatly impressed with the passion each lecture has been taught with as well as information that has been communicated. Each lecture was interesting and definitely left me wanting to do some wider reading too. In my time at UCL, I probably haven't enjoyed any other course I've taken as much as this one. I would like to add that this department is an asset to both yourself and UCL.
Lecturer (Dr Richard Milne): ‘FANTASTIC presentation. Clearly spoken, slow enough to take a good set of notes’.
INIM3002 Immunology in Health and Disease
Module (Lead, Dr Antony Antoniou): ‘really enjoyed!’
Lecturer (Dr Nandi Simpson): ‘Terrific, very encouraging and knowledgeable!’
INIM3003 Infectious Agents
Module (Lead, Dr Richard Milne): ‘Brilliant whistle stop tour of infectious diseases, enjoyed the holistic approach to learning and the broad array of topics covered along with the historical flavour! Great fun!’
Lecturer (Dr Indran Balakrishnan): ‘really enjoyable. Lots of context, explanation etc. so it was easy to remember and very engaging.’
INIM3004 Cellular Pathology
Module (Lead, Professor Benny Chain): ‘…the majority of lectures were both very interesting and informative’.
Guest Lecturer (Professor Sir Tim Hunt, CRUK, Nobel Laureate): ’…. Excellent speaker. Vibrant, funny and outspoken.’
INIM3005 Immunodeficiency and Therapeutics
Module (Lead, Dr Mahdad Noursadeghi): ‘interesting lectures’.
Lecturer (Dr Emma Morris): ‘good interactive lecture’.
INIM3006 Allergy, Autoimmunity and Transplantation
Module (Lead, Professor Peter Delves): 100% of students felt the module fully achieved the aims and objectives stated in the coursebook.
Guest Lecturer (Dr Alan Salama, UCL Internal Medicine): ‘Very well presented.’
INIM3007 Viruses and Disease
Module (Lead, Dr Richard Milne): ‘Superbly organised, interesting topics with a lot of scope for reading more around what interested me.’
Lecturer (Professor Paul Griffiths): ‘Really interesting lecture. Good slides.’
INIM3008 Microbial Pathogenesis
Module (Lead, Dr Bambos Charalambous): ‘my favourite module this year’.
Lecturer (Dr Bambos Charalambous): ‘one of the best lecturers in my whole 3 years at UCL. 10/10’.
INIM3009 Neoplasia and its Treatment
Module (Lead, Dr Emma Morris): ‘Good balance between the molecular mechanisms and clinical aspects of cancer.’
Guest Lecturer (Professor John Hartley, UCL Cancer Institute): ‘Fantastic lecture……really great explanations.’
VIRL3001 Molecular Virology
Module (Lead, Dr Ari Fassati): ‘Very good to look at a paper published by people at UCL and be able to talk about it with the people involved’
Lecturer (Dr Marlen Aasa-Chapman): ‘really good and interesting’.
George Gladstone (September 2010):
Presentations to the entire course also helped to enhance these skills, with valuable feedback from student and staff alike leaving me feeling much more confident in both my manner of presentation and the content that I was delivering.
The research project is the much discussed corner-stone of the course, and rightly so - choice is again key, and being able to select a project that appealed to me personally ensured that I remained interested and committed. My supervisor was very eager to help me get to grips with even the most basic techniques of lab work, along with all the other skills associated with research, and I felt involved and that I was contributing something useful towards the sum output of the lab. Being attached to labs that are at the cutting edge of research and actively making new discoveries in their various fields is highly invigorating.
I'd advice prospective students not to be put off by the mention of lab work, or the manner in which the course attempts to maintain a grounding in research - knowing even roughly how a research lab functions is very useful, as well as understanding quite how much effort goes into producing items for publication. The work involved is very satisfyingboth on the day-to-day level, in the longer term. Everyone attached to the course from the head of the department to your supervisors and lecturers remains approachable and open to requests and comments, in a manner very different from phase 1."
Bethan Goulden (August 2009):
UCL is allied to a number of institutions, including University College Hospital, Royal Free Hospital, Moorfield's Eye Hospital and Great Ormond Street Hospital, meaning that you are oftern taught by clinicians at the forefront of their field in both patient care and research. We were taught about the weird and wonderful aspects of the immune system, from the biochemical through to the clinical, from the incredible rare immunodefiency syndromes to worldwide killers such as leishmaniasis, and the devastating impact chemotherapy, transplantation, immunosuppression and AIDS wreak on the human body. Furthermore, the affiliated hospitals and research institutions provided a wealth of opportunities for the iBSc project itself: in a wide variety of fields spanning ophthalmology, virology, oncology and paediatrics.
Working in the field of autoimmunity gave me the opportunity to attend autoimmnune rheumatic disease clinics at UCH, do lab-based research and subsequently to get published. It was a hugely challenging, yet ultimately fulfilling experience, and despite the fact that it involved some hard work along the way, I had no regrets about choosing this iBSc. I spent a year learning about a topic which truly fascinated me and when I entered clinics, turned out to be genuinely useful."
For additional information, please contact the Divisional
Ms Biljana Nikolic
Page last modified on 08 jul 11 13:48 by Isabel Lubeiro