Research Department of Infection
PROFESSOR DEENAN PILLAY (HEAD OF DEPARTMENT)
(Picture; SLMS Profile; Search UCL Publications Database)
PROFESSOR JUDY BREUER
Research Group: Dr Daniel Depledge, Dr Samit Kundu, Dr Meleri Jones
Location: Cruciform Building
Contact Details: firstname.lastname@example.org
Our group studies:
VZV evolution and transmission.
Viral genetic determinants of disease and spread.
VZV rash identification programme.
CYTOMEGALOVIRUS RESEARCH GROUP
The Cytomegalovirus Research Group is based primarily at the Royal Free Campus and consists of three Principal Investigators; Professor Paul D. Griffiths, Professor Vincent C. Emery and Dr Richard Milne.
The group has a broad interest in the pathogenesis of human cytomegalovirus (HCMV) in immunocompromised hosts and the neonate with a particular focus on translational research.
Contact Details: Centre for Virology, UCL Medical School, Rowland Hill Street, NW3 2PF. Tel: 020 7830 2997. Fax: 020 7830 2854.
WOHL VIRION CENTRE
For information about the centre and its Research Team, please click here.
PROFESSOR GREG TOWERS' RESEARCH GROUP
(Professor Greg Towers: SLMS Profile)
Overview: Our lab studies how host virus interactions lead to species-specific replication of retroviruses. We use GFP encoding viruses to follow infection in cell lines and seek host factors that inhibit or facilitate infection. We consider whether these factors exhibit species specificity by cloning and expressing species variants or by reducing their expression using RNA interference. We examine relatedness between factors and consider how they have changed during evolution using phylogenetics and positive selection analyses.
Collaborations: We collaborate with Leo James at the Laboratory of Molecular Biology in Cambridge to apply biophysics and structural techniques to these questions.
Our current research questions are: How do restriction factors TRIM5 and tetherin work and can they prime adaptive immunity? How does HIV-1 avoid pattern recognition and how do uncoating and nuclear entry pathways relate to this? How does attenuated SIV infection lead to vaccination? Are herpes viruses sensitive to restriction factors? We aim to understand the molecular details of host virus interactions with a view to manipulating them therapeutically and designing better vaccines. We are funded by a Wellcome Trust Senior Fellowship and project grants from the Medical Research Council and the UCL Comprehensive Biomedical Research Centre.
Page last modified on 27 mar 12 10:42 by Isabel Lubeiro